Risk-mitigation decisions in risk-management systems are usually based on complex risk indicators. Therefore, aggregation is an important step during assessment. Aggregation when determining the of components or overall different areas organizational levels. In this article, authors identify scenarios. They summarize requirements functions and characterize aggregations according to these requir...

TDP-43 aggregation in the cytoplasm or nucleus is a key feature of the pathology of amyotrophic lateral sclerosis and frontotemporal dementia and is observed in numerous other neurodegenerative diseases, including Alzheimer's disease. Despite this fact, the inciting events leading to TDP-43 aggregation remain unclear. We observed that endogenous TDP-43 undergoes reversible aggregation in the nu...

A π-conjugated urea-bearing phenyleneethynylene polymer (Poly-2) was rationally designed by the Sonogashira coupling condensation reaction and had been demonstrated to have a unique fluorescent quenching effect for optical detection of all determined anions, especially CN−. The emission Poly-2 significantly quenched upon adding CN−, together accompanied with continuous red shift peak from 442 4...

1Research Institute, National Center for Geriatrics and Gerontology, Obu, Aichi 474-8522, Japan 2Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille (CRN2M), Université de la Méditerranée Aix-Marseille II et Université Paul Cézanne Aix-Marseille III, CNRS UMR 6231, INRA USC 2027, 13284 Marseille Cedex 07, France 3Department of Medical Biophysics, Ontario Cancer Institute, Univ...

Asphaltenes from four different crude oils (Arab Heavy, B6, Canadon Seco, and Hondo) were fractionated in mixtures of heptane and toluene and analyzed chemically, by vapor pressure osmometry (VPO), and by small angle neutron scattering (SANS). Solubility profiles of the asphaltenes and their subfractions indicated strong cooperative asphaltene interactions of a particular subfraction that is po...

The aggregation behavior of the antibiotic moenomycin A (MoA) in aqueous solution under the influence of pH and ionic strength has been investigated using the fluorescent probe pyrene. Changes of the cmc between 0.03 and 0.7 mM correlate with the effective charge of MoA originating from three ionizable groups, the pKa of which have been determined by infrared spectroscopy. The dependence of the...

In the social amoebae Dictyostelium discoideum, periodic synthesis and release of extracellular cyclic adenosine 3',5'-monophosphate (cAMP) guide cell aggregation and commitment to form fruiting bodies. It is unclear whether these oscillations are an intrinsic property of individual cells or if they exist only as a population-level phenomenon. Here, we showed by live-cell imaging of intact cell...

This paper describes research on four web-based learning applications that employ a variety of assessment approaches and student tracking and data aggregation mechanisms. These applications are aimed at promoting deeper learning in web-based learning applications and courses and at facilitating a researchbased, design experiment approach to prototype development and improvement. Developmental r...

The invasive multicolored Asian ladybeetle, Harmonia axyridis (Pallas) (Coleoptera: Coccinellidae), aggregates inside dwellings during winter to avoid cold weather. This adaptive behavior disturbs homeowners, because of the large numbers of individuals that aggregate, which induces allergic reactions. The migratory flight patterns of this species have been well documented, with individuals pref...

Fishing overcapacity has lead to unsustainable harvesting and rent dissipation in global fisheries. Only government intervention of some kind can lead to a reduction in capacity. If efficiency is the primary objective for the regulator, then the least efficient vessels should be decommissioned. Here we analyze the Swedish fishery using a panel of individual fishing trip observations. Trip data ...