Cytolethal distending toxin (CDT) is found in Gram-negative bacteria, especially in certain Proteobacteria such as the Pasteurellaceae family, including Haemophilus ducreyi and Aggregatibacter (Actinobacillus) actinomycetemcomitans, in the Enterobacteriaceae family and the Campylobacterales order, including the Campylobacter and Helicobacter species. In vitro and in vivo studies have clearly sh...

Periodontitis is one of the most common chronic inflammatory diseases. The etiology is clearly bacterial and a number of putative bacterial pathogens have been associated with the disease, including Aggregatibacter actinomycetemcomitans, Tannerella forsythus and Porphyromonas gingivalis. Comparatively, little attention has been paid to the identification of health-associated and potentially ben...

Protamine was investigated for its antibacterial activity against the periodontal pathogens, Porphyromonas gingivalis, Prevotella intermedia and Aggregatibacter actinomycetemcomitans. We determined the minimum inhibitory concentrations of protamine and its hydrolysate and their bactericidal activity. Protamine inhibited the growth of all periodontopathic bacteria tested on agar plates. Protamin...

The periopathogen Aggregatibacter actinomycetemcomitans is associated with aggressive periodontitis, a severe disease that causes rapid tooth loss among young adolescents. A. actinomycetemcomitans produce and secrete leukotoxin a pore forming protein which causes death of human polymorphonuclear leukocytes (PMNs) such as neutrophils. PMNs are the most abundant leukocyte and have important defen...

BACKGROUND: Oral infections associate statistically with cancer. OBJECTIVE: We hypothesized that certain periodontal microorganisms might specifically link to malignancies in general and set out investigate this our ongoing cohort study. METHODS: A sample of 99 clinically examined patients from 1676 subjects was used the associations between harboring Aggregatibacter actinomycetemcomitans (A.a)...

Background. Aggregatibacter actinomycetemcomitans (Aa) plays a vital role in some destructive forms of periodontitis. While mechanical and chemical plaque control is the first step periodontitis treatment, side effects adjunctive agents such as chlorhexidine (CHX) mouthwash have led to application natural alternatives with minimal effects. Therefore, this study evaluated antibacterial effect hy...

Aggregatibacter actinomycetemcomitans is an oral pathogen and etiologic agent of localized aggressive periodontitis. The bacterium is also a cardiovascular pathogen causing infective endocarditis. A. actinomycetemcomitans produces leukotoxin (LtxA), an important virulence factor that targets white blood cells (WBCs) and plays a role in immune evasion during disease. The functional receptor for ...