background: cutaneous leishmaniasis caused by l. major is an important public health problem in endemic areas. the aim of this study was to explore the therapeutic effect of microwave and or infrared radiation in the treatment of lesion induced in balb/c mice by l. major inoculation. methods: the footpad lesion was induced in balb/c mice by inoculation of l. major promastigotes subcutaneously. ...

background: peroxisome proliferator activated receptor gamma (pparγ), a member of nuclear receptor superfamily, comprises two isoforms in mouse. these two isoforms are encoded by different mrnas, which are arisen by alternative promoter usage. there are two promoter regions upstream of pparγ gene. a 3 kb fragment, containing several transcription factor binding sites, acts as pparγ1 promoter re...

background fluoxetine (flx), a selective serotonin reuptake inhibitor, is widely used in the treatment of neurological disorders. however, its application carries the risk of adverse reactions, including reproductive toxicities. grape seed is highly regarded for its pharmacological activities, specifically its antioxidant properties. objectives this study was designed to evaluate whether hydroa...

introduction: lansoprazole is one of the proton pump inhibitor drugs widely used in the treatment of gastro-duodenal ulcers and disorders. however, there is not enough data about unexplored adverse effects of lansoprazole on the integrity of the placental barrier. therefore, the present study was conducted to determine whether placental structure could be affected by lansoprazole administration...

background: heroin as opium is being used in two pure and impure forms with known disastrous effects on different body organs including genital system. the aim of this study was to determine the changes in testosterone secretion, the percentage of fertility, changes of the body and testis weight, and gonado somatic index in mice (ballb/c). materials and methods: a total of 90 adult male and fem...

aim : to create an orthotopic hepatoma model with local metastasis monitored with ultrasound could be created as a platform for testing new treatments.   background : hepatoma accounts for 25% of liver tumors in children with poor overall survival. intraabdominal metastasis are present in 35% of patients at time of diagnosis.  we hypothesized that an orthotopic tumor model with local metastasis...

Deficits in autonomic thermoregulatory capacities have been identified in aged humans and animals, but little is known about the effect of aging on behavioral thermoregulation and the potential effect of season. Preferred ambient temperature (T(a)) in a thermal gradient (available T(a)s from 10 to 30 degrees C) was measured in the mouse lemur, a nocturnal Malagasy primate. Male mouse lemurs (40...

Neuromuscular junction degeneration is a prominent aspect of sarcopenia, the age-associated loss of skeletal muscle integrity. Previously, we showed that muscle stem cells activate and contribute to mouse neuromuscular junction regeneration in response to denervation (Liu et al., 2015). Here, we examined gene expression profiles and neuromuscular junction integrity in aged mouse muscles, and un...

  The high prevalence of dementia in aged individuals suggests that aging is the most important risk factor and that senescence further enhances dementia. We have searched for dietary factors that prevent brain senescence using a mouse model of age-related neurodegeneration (SAMP10). This mouse line is suitable for studying brain senescence because brain atrophy and cognitive dysfunction are ob...

GDF11 has recently emerged as a powerful anti-aging candidate, found in young blood, capable of rejuvenating a number of aged tissues, such as heart, skeletal muscle and brain. However, recent reports have shown contradictory data questioning its capacity to reverse age-related tissue dysfunction. The availability of a mouse model of accelerated aging, which shares most of the features occurrin...