Data on mortality for the ten years following lower limb amputation were obtained from all the 16 surgical units in Southern Finland and the National Social Insurance Institution. In Southern Finland during the period 1984-1985, amputations of the lower limb were performed on 705 patients, of whom 382 (54%) were women and 323 (46%) men. The majority of the amputations, 47% were performed for va...

Data on mortality for the ten years following lower limb amputation were obtained from all the 16 surgical units in Southern Finland and the National Social Insurance Institution. In Southern Finland during the period 1984-1985, amputations of the lower limb were performed on 705 patients, of whom 382 (54%) were women and 323 (46%) men. The majority of the amputations, 47%, were performed for v...

Records of Angus, Hereford, Shorthorn, and first-cross cows born from 1960 to 1963 were used to study the effect of age at first calving and culling policy on cumulative survival (SU), number of breeding seasons (BS), pregnancies (PG), calves born (CB) and alive at 72 h (C72) and at weaning (CW), calf weaning weights (WW), and input/output efficiency, up to 12 yr of age. The 155 cows born in 19...

Acute kidney injury (AKI), as defined by the precipitous decline in GFR, is frequently encountered in the elderly. The effect of advancing age in decreasing renal reserve and the associated comorbid conditions of elderly patients increase the risk for the development of AKI. Although studies describing the incidence of AKI in this population are difficult to compare because the definitions of A...

A novel nonnucleoside inhibitor of hepatitis C virus (HCV) RNA-dependent RNA polymerase (RdRp), [(1R)-5-cyano-8-methyl-1-propyl-1,3,4,9-tetrahydropyano[3,4-b]indol-1-yl] acetic acid (HCV-371), was discovered through high-throughput screening followed by chemical optimization. HCV-371 displayed broad inhibitory activities against the NS5B RdRp enzyme, with 50% inhibitory concentrations ranging f...

Csiszar A, Labinskyy N, Orosz Z, Xiangmin Z, Buffenstein R, Ungvari Z. Vascular aging in the longest-living rodent, the naked mole rat. Am J Physiol Heart Circ Physiol 293: H919–H927, 2007. First published April 27, 2007; doi:10.1152/ajpheart.01287.2006.— The naked mole rat (NMR; Heterocephalus glaber) is the longestliving rodent known [maximum lifespan potential (MLSP): 28 yr] and is a unique ...

The naked mole rat (NMR; Heterocephalus glaber) is the longest-living rodent known [maximum lifespan potential (MLSP): >28 yr] and is a unique model of successful aging showing attenuated declines in most physiological function. This study addresses age-related changes in endothelial function and production of reactive oxygen species in NMR arteries and vessels of shorter-living Fischer 344 rat...

Tracheal mucous velocity measurements were made in 24 beagle dogs in five age groups, using a gamma camera to detect movement of instilled 99mTc-macroaggregated albumin. Age groups were defined as immature (9-10 mo), young adult (2.8-3.0 yr), middle aged (6.7-6.9 yr), mature (9.6-9.8 yr), and aged dogs (13.6-16.2 yr). Mean velocities were 3.6 +/- 0.4 (SE) mm/min in the immature dogs, 9.7 +/- 0....

Hearing loss accompanied with middle ear effusion was analyzed according to audiometric frequencies for different age group. Results for left and right ears were compared in/and between study and control group. Pure tone audiometry for bone and air conduction and tympanometry was performed in study group of ninety-eight children with conductive hearing loss and otitis media with effusion. Contr...