OBJECTIVE To evaluate the efficacy and safety of bupropion in the treatment of apathy in Huntington's disease (HD). METHODS In this phase 2b multicentre, double-blind, placebo-controlled crossover trial, individuals with HD and clinical signs of apathy according to the Structured Clinical Interview for Apathy-Dementia (SCIA-D), but not depression (n = 40) were randomized to receive either bup...

BACKGROUND Apathy is a common neuropsychiatric symptom in Alzheimer's disease (AD) dementia and mild cognitive impairment (MCI). Detecting apathy accurately may facilitate earlier diagnosis of AD. The Apathy Evaluation Scale (AES) is a promising tool for measurement of apathy in prodromal and possibly preclinical AD. OBJECTIVE To compare the three AES sub-scales - subject-reported (AES-S), in...

Abstract— These In today’s world data security is the major problem which is to be face. In order to secure data during communication, data storage and transmission we use Advance encryption standard(AES). AES is a symmetric block cipher intended to replace DES for commercial applications.it uses 128-bit block size and a key size of 128, 192, or 256 bits. The AES algorithmis use to secure data ...

Background Mild to moderate adverse events (AEs) are common after treatment of lymphatic filariasis (LF) and pose a major challenge for the global LF elimination program. We studied changes in cytokine levels and filarial worm components in plasma of subjects with and without AEs following treatment of LF. Methods Participants (n = 24) were hospitalized and monitored for AEs following treatme...

PURPOSE To assess the incidence and severity of adverse events (AE) associated with cardiovascular magnetic resonance (CMR) in a large cohort of patients with congenital heart disease and to identify independent risk factors for their occurrence. METHODS AEs were prospectively recorded from October 2002 through December 2004 and graded by 3 independent observers for severity, preventability, ...

In 2002, Murphy and Robshaw introduced an extension BES of AES and argued this could compromise the security of AES. We introduce here two block-ciphers CES and Big-BES that are some extensions of the AES and BES respectively in the spirit of Hensel lifting extensions. They are defined similarly to the AES respectively BES except that every operations are performed in a ring structure including...

In this paper, we revisit meet-in-the-middle attacks on AES in the single-key model and improve on Dunkelman, Keller and Shamir attacks of Asiacrypt 2010. We present the best attack on 7 rounds of AES-128 where data/time/memory complexities are below 2. Moreover, we are able to extend the number of rounds to reach attacks on 8 rounds for both AES-192 and AES-256. This gives the best attacks on ...

PURPOSE Analysis of overall tolerability and neurological adverse effects (AEs) of eslicarbazepine acetate (ESL), lacosamide (LCM) and oxcarbazepine (OXC) from double-blind, placebo-controlled trials. Indirect comparisons of patients withdrawing because of AEs, and the incidence of some vestibulocerebellar AEs between these three antiepileptic dugs (AEDs). METHODS We searched MEDLINE for all ...