BACKGROUND The long-acting muscarinic antagonist (LAMA) umeclidinium (UMEC) and the combination of UMEC with the long-acting β2-agonist (LABA) vilanterol (UMEC/VI) are approved maintenance treatments for chronic obstructive pulmonary disease (COPD) in the US and EU. They are not indicated for the treatment of asthma. METHODS In this 52-week, double-blind, placebo-controlled, parallel-group sa...

Alex Biryukov and Dmitry Khovratovich presented related-key attacks on AES and reduced-round versions of AES. The most impressive of these were presented at Asiacrypt 2009: related-key attacks against the full AES-256 and AES-192. We discuss the applicability of these attacks and related-key attacks in general. We model the access of the attacker to the key in the form of key access schemes. Re...

Japanese Encephalitis (JE) is a vector-borne disease of major importance in Asia. Recent increases in cases have spawned the development of more stringent JE surveillance. Due to the difficulty of making a clinical diagnosis, increased tracking of common symptoms associated with JE-generally classified as the umbrella term, acute encephalitis syndrome (AES) has been developed in many countries....

BACKGROUND The aim of the present study was to investigate the incidence of adverse events (AEs) during intra-hospital transport (IHT) of critically ill patients and evaluate the risk factors associated with these events. METHODS This prospective multicenter observational study was performed in 34 intensive care units in China during 20 consecutive days from 5 November to 25 November 2012. Al...

The Intel® Advanced Encryption Standard (AES) New Instructions (AES-NI) were designed to implement some of the complex and performance intensive steps of the AES encryption/decryption algorithm (cipher) using hardware acceleration. This paper presents the outcomes of a research project aimed at encryption/decryption analysis of the AES cipher in ECB, CBC, OFB, CFB, and CTR modes of operation on...

OBJECTIVES The goal of this study was to determine the association of first pass success with the incidence of adverse events (AEs) during emergency department (ED) intubations. METHODS This was a retrospective analysis of prospectively collected continuous quality improvement data based on orotracheal intubations performed in an academic ED over a 4-year period. Following each intubation, th...

Vaccinations often induce various adverse events (AEs), and sometimes serious AEs (SAEs). While many vaccines are used in combination, the effects of vaccine-vaccine interactions (VVIs) on vaccine AEs are rarely studied. In this study, AE profiles induced by hepatitis A vaccine (Havrix), hepatitis B vaccine (Engerix-B), and hepatitis A and B combination vaccine (Twinrix) were studied using the ...