نتایج جستجو برای: aerobic cell
تعداد نتایج: 1713074 فیلتر نتایج به سال:
Targeting defects in metabolism is an underutilized strategy for the treatment of cancer. Arginine auxotrophy resulting from the silencing of argininosuccinate synthetase 1 (ASS1) is a common metabolic alteration reported in a broad range of aggressive cancers. To assess the metabolic effects that arise from acute and chronic arginine starvation in ASS1-deficient cell lines, we performed metabo...
The inhibitory effect of Oncovin (vincristine sulfate) on cell division was studied in human cell line NHIK 3025. Oncovin arrested the cells in metaphase at concentrations as low as 10(-3) mug/ml. At 8 X 10(-3) mug/ml and higher concentrations, the arrest was complete after 6 hr of treatment. The arrest was irreversible after exposure for 6 hr to 16 X 10(-3) mug Oncovin per ml. The X-ray radios...
Glycolytic activity of rat peritoneal mast cells has been measured by the Cartesian ampulla diver technique. The rates of anaerobic glycolysis, expressed as CO(2) expelled from a bicarbonate medium, are 1.70 x 10(-6) microl and 1.43 x 10(-6) microl per cell per hour with and without glucose, respectively. The aerobic glycolysis rate in the presence of glucose, assuming the respiratory quotient ...
Aerobic granules are self-immobilized aggregates of microorganisms and represent a relatively new form of cell immobilization developed for biological wastewater treatment. In this study, both culture-based and culture-independent techniques were used to investigate the bacterial diversity and function in aerobic phenol- degrading granules cultivated in a sequencing batch reactor. Denaturing gr...
Mitochondrial myopathies with respiratory chain defects are multisystem diseases characterised by mitochondrial DNA (mtDNA) mutations responsible for impairment of aerobic cell metabolism. At the skeletal muscle level involvement of respiratory chain function is the cause of insufficient ATP production and deranged metabolism, a main effect of which is represented by abnormal production of lact...
Mitomycin C (MMC) induced aerobic and hypoxic Cytotoxicity in Chinese hamster V79 cells was studied to evaluate the role of the 1electron versus 2-electron reductive bioactivation. Superoxide dismutase, catatase, and desierai had no protective effects on the aerobic or hypoxic Cytotoxicity of MMC, whereas Tempol and Tempol-H, which are known to interrupt and terminate radical reactions, provide...
How metabolism is reprogrammed during neuronal differentiation is unknown. We found that the loss of hexokinase (HK2) and lactate dehydrogenase (LDHA) expression, together with a switch in pyruvate kinase gene splicing from PKM2 to PKM1, marks the transition from aerobic glycolysis in neural progenitor cells (NPC) to neuronal oxidative phosphorylation. The protein levels of c-MYC and N-MYC, tra...
To gain insight into the cell envelope of Escherichia coli grown under aerobic and anaerobic conditions, lipoproteins were examined by using functional genomics. The mRNA expression levels of each of these genes under three growth conditions--aerobic, anaerobic, and anaerobic with nitrate--were examined by using both Affymetrix GeneChip E. coli antisense genome arrays and real-time PCR (RT-PCR)...
Mitomycin C (MMC) induced aerobic and hypoxic Cytotoxicity in Chinese hamster V79 cells was studied to evaluate the role of the 1electron versus 2-electron reductive bioactivation. Superoxide dismutase, catatase, and desierai had no protective effects on the aerobic or hypoxic Cytotoxicity of MMC, whereas Tempol and Tempol-H, which are known to interrupt and terminate radical reactions, provide...
Classical ideas for early eukaryotic evolution often posited a period of anaerobic evolution producing a nucleated phagocytic cell to engulf the mitochondrial endosymbiont, whose presence allowed the host to colonize emerging aerobic environments. This idea was given credence by the existence of contemporary anaerobic eukaryotes that were thought to primitively lack mitochondria, thus providing...
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