Carcinogenicity data of medicinal products for human use that have been authorised via the European centralised procedure (CP) between 1995 and 2009 were evaluated. Carcinogenicity data, either from long-term rodent carcinogenicity studies, transgenic mouse studies or repeat-dose toxicity studies were available for 144 active substances contained in 159 medicinal products. Out of these compound...

The derivation of safe levels of exposure in humans for compounds that are assumed to cause threshold toxicity has relied on the application of a 100-fold uncertainty factor to a measure for the threshold, such as the no observed adverse effect level (NOAEL) or the benchmark dose (BMD). This 100-fold safety factor consists of the product of two 10-fold factors allowing for human variability and...

background: the surveillance of adverse events following immunization (aefi) is essential to improve high standard of vaccine safety, and maintain public trust in immunization programs. this study aimed to determine the aefi and their related factors in children. materials and methods: this cross-sectional study including all children under 7- year of age, in hamadan province, the west of iran,...

the serious influenza-associated complications among immunodeficient individuals such as those who are infected with human immunodeficiency virus (hiv), highlights the importance of influenza vaccination in these people. therefore, the current study aimed to investigate the antibody responses to influenza vaccine in this group. two hundred subjects were recruited, during autumn 2010 and 2011, t...

leukotriene receptor antagonists(montelukast) have been used for many years in the treatment of asthma both acute and chronic stages. they are accepted commonly as safe but mostly possible side effects are ignored. however, montelukast also could lead to important adverse reactions like hallucinations. in literature only 2 reports have been found about hallucinations with it. one is a study whi...

how to cite this article: karimzadeh p, bakrani v. antiepileptic drug-related adverse reactions and factors influencing these reactions. iran j child neurol. 2013 summer; 7(3):23-27.   objective according to the basic role of drug side effects in selection of an appropriate drug, patient compliance and the quality of life in epileptic patients, and forasmuch as new dugs with unknown side effect...

case presentation we present a case of a grade iii coronary perforation in which the double guiding catheter technique helped us to deliver the graft stent. conclusions the double-guiding technique is useful in emergency situations to increase the safety and efficacy of sealing a coronary perforation. introduction coronary vessel perforation is one of the most feared complications of coronary a...

introduction toxoplasma gondii is one of the most important pathogen that has adverse effect on reproductive function. evidence acquisition recent studies revealed that infection with t. gondii not only affect female reproduction, also cause male reproductive impairment. in clinical studies, high prevalence of toxoplasmosis in sterile men has been reported. in animal models, toxoplasmosis is as...