In the developing PNS, axonal neuregulin-1 (NRG1) type III is the key determinant for myelination. However, the specific role for NRG1 (III) in the CNS has not been established. To address this issue, isotype-specific antibodies were generated, characterized, and used for the immunofluorescent localization of NRG1 (III) in the developing and adult CNS of rat. In contrast to adult peripheral ner...

Adult neurogenesis, or the creation of new neurons in adult organisms, is an exciting recent area of neurological research. The subgranular zone of the adult hippocampus is one area where hippocampal neural progenitors generate new neurons that functionally integrate into existing neuronal circuitry. Given the role that the hippocampus plays in learning and memory consolidation and its vulnerab...

a,-Adrenergic receptor (AR) activation in cardiac muscle has several different physiological effects that might be mediated through different a,-AR subtypes. Two a,-AR subtypes have been cloned from the rat, the alB and the alD; both are present in adult rat heart. A third subtype, the a,c, cloned from the cow and human, was reported to be absent in the rat. However, we recently found alc mRNA ...

Background: The aim of this study was to investigate the effects of hydroalcoholic extract of lepidium sativum(LS) on sperm parameters in adult rat. Materials and Methods: Male adult rats were divided into three groups: control group (n=5) received normal salin; group2: received 200 L.S extract; group3: received 400 LS extract. All groups were treated for 21 days. Evaluations were made by hysto...

objective(s): stem cell therapy is believed to be as a promising treatment strategy for tissue repair and regeneration. the plasticity specification of the adult stem cells, such as mscs, has enabled that these cells to be used in the treatment of a broad spectrum of diseases like liver disorders. in this study, the production of urea and albumin (alb), glycogen storage, and expression of some ...

Axotomy-induced motor neuron death occurs within a week in the neonatal rat and mouse. However, slowly progressive motor neuron death, which takes more than a month, occurs after axotomy in the adult mouse (C57BL/6) but not in the adult rat (Wistar). Here we demonstrate that expression of a p53-inducible Bcl-2 homology domain 3 (BH3)-only protein, Noxa, is enhanced in axotomized neurons of the ...

Neurogenesis occurs throughout adult life in rat dentate gyrus. Factors and mechanisms of adult neurogenesis regulation are not well known. Vitamin E deficiency has been found to deliver a neurogenetic potential in rat dorsal root ganglia. To determine whether the role of tocopherols in adult neurogenesis may be generalized to the central nervous system, changes in adult rat dentate gyrus neuro...