Mouse testicular experimental models are widely used in the study of andrology, reproductive toxicology and pharmacology. Under physiological conditions, a normal adult mouse is usually considered to have normal testes. However, whether normal adult mouse testes exhibit pathological changes has not been evaluated. The objective of this study was to investigate the pathological changes of testic...

Background: Mesenchymal stem cells (MSCs) can be used to treat premature ovarian failure (POF). Different methods have already been applied to detect MSCs in tissues. This study aimed to investigate the quantitative distribution of CM-DiI-labeled human umbilical cord vein MSCs (hUCV-MSCs) in different regions of the ovarian tissue of the cyclophosphamide ( CTX )-induced POF in mice. Methods: Ad...

background: lead is an industrial heavy metal that can decrease sperm motility. objective: the aim was to investigate the protective effects of calcium against lead on motility of spermatozoa. materials and methods: in total 40 adult male swiss white mice were randomly divided into 5 groups (control, lead of 1st wk, lead of 2nd wk, lead/calcium of 1st wk and lead/calcium of 2nd wk). the lead gr...

BACKGROUND In the recent years, the use of Doppler-echocardiography has become a standard non-invasive technique in the analysis of cardiac malformations in genetically modified mice. Therefore, normal values have to be established for the most commonly used inbred strains in whose genetic background those mutations are generated. Here we provide reference values for transthoracic echocardiogra...

Analysis of protein kinase B (AKT) and S6 kinase1 (p70S6K) activity is widely used to assess the efficacy of interventions designed to increase or maintain skeletal muscle mass; these studies are often performed on feed-deprived mice. One problem associated with feed deprivation is that it promotes catabolism, and young or metabolically compromised mice may have less tolerance. The aim of our s...

Generalist mice are key species for the long-term dynamics of fragmented forests due to their dual role as seed dispersers or predators dominant trees. Wood mice, Apodemus sylvaticus, usually act a net predator in woodlots higher winter densities and earlier reproduction than forests. Here we analyze recruitment expectations young born relation food availability through an index developmental s...

Abstract Study question To explore the role of Mitochondrial fission factor (MFF) in female fertility and oocyte development using a Mff knockout mouse model. Summary answer deficiency influences mitochondrial dynamics oocytes at germinal vesicle stage (GV), results premature ovarian failure (POF) infertility. What is known already regulates quality control (MQC) by influencing dynamics. MQC ha...

background: in recent years, the widespread use of microwave producing instruments specially mobile phones; result in growing concern regarding the possible effects associated with these waves on human health. in the present study investigated the genotoxic effects of mobile phone radiation in adult mice (balb/c) and their embryos. methods: in this experimental research pregnant mice were irrad...