OBJECTIVES The purpose of this study was to assess the frequency and correlates of documented advance directives (ADs) among patients hospitalized for heart failure (HF). BACKGROUND Discussing ADs with patients with HF is critical for identifying treatment goals consistent with patients' values and preferences and for facilitating health care team communication. METHODS We retrospectively i...

BACKGROUND Medical treatment of levodopa-induced dyskinesia (LID) in Parkinson's disease (PD) is an unmet need. ADS-5102 (amantadine) extended-release capsules is being developed for the treatment of LID in patients with PD. OBJECTIVE Evaluate the long-term safety and tolerability of 274 mg ADS-5102 for LID in PD. METHODS In an ongoing, open-label safety study (NCT02202551), PD patients wit...

OBJECTIVE Childhood obesity is a growing problem in the USA. As parents play a major role in shaping a child's diet, the present study examines food advertisements (ads) directed towards parents in parenting and family magazines. DESIGN Given the potential for magazines to influence attitudes and knowledge, we used content analysis to examine the food ads appearing in four issues each of six ...

Correspondence to Dr Mario Cárdaba Arranz; [email protected] ABSTRACT Objective: To estimate the attributable and targeted avoidable deaths (ADs; TADs) of outdoor air pollution by ambient particulate matter (PM10), PM2.5 and O3 according to specific WHO methodology. Design: Health impact assessment. Setting: City of Valladolid, Spain (around 300 000 residents). Data sources: Demographics; mor...

BACKGROUND There is evidence that Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is accompanied by gastro-intestinal symptoms; and IgA and IgM responses directed against lipopolysaccharides (LPS) of commensal bacteria, indicating bacterial translocation. METHODS This study was carried out to examine gastro-intestinal symptoms in subjects with ME/CFS versus those with chronic fati...

OBJECTIVE To estimate the attributable and targeted avoidable deaths (ADs; TADs) of outdoor air pollution by ambient particulate matter (PM10), PM2.5 and O3 according to specific WHO methodology. DESIGN Health impact assessment. SETTING City of Valladolid, Spain (around 300 000 residents). DATA SOURCES Demographics; mortality; pollutant concentrations collected 1999-2008. MAIN OUTCOME M...

The inhibition behavior of N,N′-bis(2,4,6-trihydroxyacetophenone)-propandiimine (THAPP) as an environmentally friendly Salen Ligand on the corrosion inhibition of mild steel was studied in alkaline solution (pH=10) containing 3% NaCl. Measurements were carried out using electrochemical and surface techniques. The experimental results suggested that this compound was an ...

BACKGROUND Although the autoimmune polyglandular syndrome type 3 (APS-3) is the commonest APS that may be encountered in pediatric age, last year literature includes only few studies aiming to specifically ascertain the clinical spectrum of APS-3 in childhood and adolescence. Aims of these study were: a) to ascertain how many young patients with apparently isolated Hashimoto's thyroiditis (HT) ...

PURPOSE This study identifies risk factors, including incident disability, for the use of assistive devices (ADs) among older people. DESIGN AND METHODS Three waves of data from the National Long-Term Care Survey (NLTCS) are used to examine whether upper and lower body disability lead to use of ADs (both number of devices used and number of activities of daily living domains for which ADs are...

Using a novel field experimental design, we rigorously tested the effectiveness of an online banner ad in changing political attitudes. We find that attitudes towards the #blacklivesmatter campaign’s issues were unaffected by a week’s worth of exposure ads. This null result cannot be attributed to small sample sizes or noisy outcome measures: Our experiment was powerful enough to detect even sm...