PURPOSE Allelic losses [loss of heterozygosity (LOH)] at the 17p13 locus are frequent (85%) in adrenocortical cancers. The tumor suppressor gene TP53 is located at 17p13. The aim of the study was to determine the frequency of TP53 somatic inactivating mutations in adrenocortical tumors with 17p13 LOH and their clinico-biological correlations. EXPERIMENTAL DESIGN TP53 somatic mutations, intrag...

Peptide analogues targeting various neuropeptide receptors have been used effectively in cancer therapy. A hallmark of adrenocortical tumor formation is the aberrant expression of peptide receptors relating to uncontrolled cell proliferation and hormone overproduction. Our microarray results have also demonstrated a differential expression of neuropeptide hormone receptors in tumor subtypes of ...

BACKGROUND Discrimination between benign and malignant tumors is a challenging process in pediatric adrenocortical tumors. New insights in the metabolic profile of pediatric adrenocortical tumors may contribute to this distinction, predict prognosis, as well as identify new molecular targets for therapy. The aim of this work is to characterize the expression of the metabolism-related proteins M...

Many papers have been published concerning the effects of neuroleptanalgesia and anaesthesia on cardiovascular, respiratory and metabolic functions. However, no report has been published regarding its effect on adrenocortical function. Since neuroleptanaesthesia (NLA) diminishes cardiovascular sensitivity to adrenaline and noradrenaline (Janssen et al., 1963), it seems to be important from the ...

Three patients admitted to the intensive care unit after multiple injury were observed to suffer episodes of adrenocortical insufficiency suggested by clinical manifestations and confirmed by appropriately low cortisol concentrations. This prompted a prospective study of pituitary-adrenocortical function in six multiply injured patients, three of whom showed evidence of adrenocortical suppressi...

Altricial birds grow rapidly during post-hatching period and are developmentally sensitive to variations in food supply. Limited food results in elevated corticosterone levels in chicks of semi-precocial birds but it is not clear whether altricial songbirds show similar adrenocortical stress response to nutritional restrictions during early development. It is also unknown how nutritional stress...

It is well known that prolonged treatment with corticosteroids interferes with normal adrenocortical function, causing involvement or atrophy of the gland. This was first demonstrated in animals by Ingle and Kendall (1937) with adrenocortical extracts. Since the introduction of cortisone in clinical medicine, a great deal of evidence has accumulated concerning adrenocortical hypofunction or atr...

The incidence of adrenocortical tumors in children from the Southern region of Brazil is higher than in other parts of the world. This fact has been related to the identification of an inherited missense mutation of the p53 (R337H) at high frequency (78-97%) in Brazilian children with adrenocortical tumors. Given the high frequency of this germline mutation in the Brazilian population, it is ve...

A 20-month-old female presented with respiratory distress and a right adrenal mass extending into the inferior vena cava and right atrium. The mass was initially thought to be neuroblastoma. Pathology later revealed adrenocortical carcinoma. Inferior vena cava extension is far more common in adrenocortical carcinoma than neuroblastoma, and its presence should prompt clinical and laboratory eval...

Metachronous bilateral adrenocortical adenomas causing adrenocorticotropic hormone-independent Cushing's syndrome is a surgical case that scarcely occurs. A 38-year-old woman diagnosed with bilateral adrenocortical adenomas one by one in 2006 and 2013. Both of the two adenomas were functional and caused typical Cushingoid symptoms. The patient underwent a laparoscopic adrenolectomy in 2006 and ...