Materials and methods In 312 Belgian children (5-12y) of the ChiBS study, the two-year longitudinal stress-lifestyle-adiposity relation was examined. Stress data (sum score of negative events, problem behaviour and negative emotions), lifestyle (food consumption, psychological eating behaviour, physical activity by accelerometry, screen time, sleep duration) and adiposity (BMI, fat% by BodPod, ...

Visceral adipose tissue predicts an unfavorable cardiovascular and metabolic risk profile in humans. Existing methods to assess visceral adipose tissue have been limited. Thus, echocardiographic assessment of epicardial adipose tissue as a marker of visceral adiposity was suggested. The technique has been shown to be a very reliable method and an excellent measure of visceral adiposity. In this...

O besity and abdominal adiposity have been shown in prospective studies to be risk factors for cardiovascular disease and particularly for diabetes (1–8). In cross-sectional studies, both are related with risk factors for these diseases (9–12), but there are few publications on the effects of changes in abdominal adiposity (13). We characterized men and women who gained and lost abdominal adipo...

Polycystic ovary syndrome (PCOS) is a complex disorder with heterogenous phenotypes and unclear etiology. A recent phenotypic clustering study identified metabolic reproductive subtypes of PCOS. We hypothesize that the heterogeneity PCOS manifestations reflects different mechanistic pathways can be using genetic approach. applied k-means to categorize genome-wide significant variants into clust...

Studies of leukocyte telomere length (LTL) and adiposity have produced conflicting results, and the relationship between body mass index (BMI) and telomere length throughout life remains unclear. We therefore tested association of adult LTL measured in 5,598 participants with: i) childhood growth measures (BMI and age at adiposity rebound (AR)); ii) change in BMI from childhood to adulthood and...

Obesity is a global health hazard and has been linked to numerous metabolic complications such as dyslipidemia, type II diabetes, & cardio vascular diseases and is negatively associated to the pulmonary function. The mechanism for this association is still debated and the best marker of adiposity in relation to dynamic pulmonary function is still not clear. We assessed the association of respir...

Background and objectives: In many settings, partnered, invested fathers have lower testosterone than single men or fathers who are not involved in caregiving. Reduced testosterone has been identified as a risk factor for multiple chronic diseases, and men's health also commonly varies by life history status. There have been few tests of whether variation in testosterone based on partnering and...

Distinct populations of leptin-sensing neurons in the hypothalamus, midbrain, and brainstem contribute to the regulation of energy homeostasis. To assess the requirement for leptin signaling in the hypothalamus, we crossed mice with a floxed leptin receptor allele (Leprfl) to mice transgenic for Nkx2.1-Cre, which drives Cre expression in the hypothalamus and not in more caudal brain regions, ge...

We examined mean effects and variance moderating effects of measures of physical activity and fitness on six measures of adiposity and their reciprocal effects in a subsample of the population-representative Danish Twin Registry. Consistent with prior studies, higher levels of physical activity suppressed variance in adiposity, but this study provided further insight. Variance suppression appea...