نتایج جستجو برای: adiponectin gene
تعداد نتایج: 1149293 فیلتر نتایج به سال:
BACKGROUND Adiponectin, a circulating adipocyte-derived protein, has insulin-sensitizing, anti-inflammatory, antiatherogenic, and cardiomyocyte-protective properties in animal models. However, the systemic effects of adiponectin in humans are unknown. Our aims were to define the metabolic profile associated with higher blood adiponectin concentration and investigate whether variation in adipone...
OBJECTIVE Adiponectin increases insulin sensitivity and contributes to insulin's indirect effects on hepatic glucose production. RESEARCH DESIGN AND METHODS To examine adiponectin's contribution to insulin action, we analyzed adiponectin levels and activation of AMP-activated protein kinase (AMPK) in insulin receptor transgenic/knockout mice (L1), a genetic model of resistance to insulin's in...
Adiponectin is a circulating adipose-derived cytokine that may act as an antioxidative and anti-inflammatory protein. Although adiponectin has been reported to exert cytoprotective effects in acute cardiac diseases, its effects on chronic heart failure are less clear. Therefore, we aimed to investigate whether adiponectin would have a beneficial effect in iron-induced chronic heart failure and ...
Studies have demonstrated that adiponectin could be a link between reproductive functions and energy metabolism in animals. The aim of the present study was to investigate the effects of prostaglandin (PG) E2 and PGF2α (10, 50, 100, 250 and 500ngmL-1) on the expression and secretion of adiponectin and its receptor genes and proteins by cultured in vitro porcine endometrial and myometrial tissue...
Objective(s):In insulin resistance, the insulin action in liver, muscles and adipocytes decreases and result in hyperglycemia, dyslipidemia and hyperinsulinemia. In this study we evaluate the effect of Zataria multiflora extract on insulin sensitivity in high fructose fed insulin resistant rats, since this extract was shown antihyperglycemic effect in streptozotocin induced diabetes in rats. ...
Adiponectin is an adipocyte-derived hormone that acts as a major regulator of energy metabolism and insulin sensitivity (1, 2). In plasma, adiponectin occurs in different forms: the trimeric low molecular weight (LMW), the hexameric middle molecular weight (MMW) and the 12-18meric high molecular weight (HMW) complexes (3). Adiponectin can be found in a smaller globular form, which is produced t...
This study investigated the effects and mechanism of actions neochlorogenic acid (3-caffeoylquinic acid; 3-CQA) on glucose lipid metabolism in rats fed a high fat-high fructose diet (HFFD). Male were HFFD (40 % lard 20 fructose) for 16 weeks. At 10th week, split into 3 groups: receiving distilled water (HFFD control group), 3-CQA 50 mg/kg metformin 200 once daily further 6 end treatment, fastin...
Variants in the CDH13 gene have been identified as determinants of blood levels of adiponectin, an insulin-sensitizing adipokine. However, their association with other metabolic risk factors remains unclear. We examined variants at CDH13 in relation to total and high-molecular-weight (HMW) adiponectin using data from a genome-wide association study performed in 2,434 Singaporean Chinese with re...
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