A series of air-stable, nitrile-ligated (cyclopentadienone)iron dicarbonyl compounds was synthesized and their activities as catalysts in the transfer reduction of acetophenone were explored. While all were active catalysts, the acetonitrile adduct was chosen for further study and was found to be active in the transfer reduction of aldehydes and ketones and in the Oppenauer-type oxidation of se...

We report the chemical synthesis and some useful applications of N-(3-pyrene)maleimide which forms fluorescent adducts with organic compounds and proteins which contain sulfhydryl groups. Lifetime of the first excited singlet state of the small molecule adducts ranged from 1.4 to 6.5 ns. Fluorescence of the protein adducts exhibited two distinct lifetimes for each adduct. The longer component h...

1,3-Dienes derived from steroidal D-ring C 17-ketones undergo Ni(II)-catalyzed hydrovinylation to give 1,2- or 1,4-addition of ethylene. Using finely tuned phosphoramidite ligands, it is possible to synthesize either the C 20 ( R)- or ( S)-derivatives without mutual contamination. The proportion of the 1,4-adduct, which is also formed stereoselectively, can be minimized by optimizing the reacti...

We have found that copper(II) compounds containing a peptide group in the chelate exhibit high activity for modification or degradation of albumin in the presence of hydrogen peroxide, whereas no activity was detected for the copper(II) compounds without an amide-group. It is suggested that presence of the amide-group in the ligand may play an important role in the formation of a peroxide adduc...

A new concept for the structural design of valence tautomeric (VT) metal complexes involving the formation of stable adducts of a tetracoordinate transition metal complex with a suitable bidentate redox-active ligand has been computationally studied using the DFT B3LYP*/6-311++G(d,p) method. The calculations, performed on a series of adducts of Co(II) diketonates with o-benzoquinone and its mon...

Macrocyclic tris-malonates incorporating cleavable di-tert-butylsilylene protecting groups have been prepared by a stepwise approach and used for the regioselective tris-functionalization of C60. Fullerene tris-adducts with an e,e,e addition pattern thus obtained. The bridging cleaved to liberate terminal alcohol functions fullerene tris-adduct. This key building block has further functionalize...

4-Dimethylaminoazobenzene (DAB, methyl yellow, or butter yellow), a human carcinogen, has been banned for use in foods since 1988. In 2014, DAB adulteration in Tofu occurred in Taiwan. We hypothesize that DAB can form [DAB•SBP]adduct adduct with soybean protein (SBP) which could damage Gastro-Duodenal-Hepatic axis. Sprague-Dawley rats gavage fed [DAB•SBP]adduct adduct revealed severely reduced ...

Benzo(a)pyrene (BP) and other polycyclic aromatic hydrocarbons (PAH) are ubiquitous environmental pollutants and are suspected to be carcinogenic in man. The in vivo formation of BP metabolite-DNA adducts has been characterized in a variety of target and nontarget tissues of mice and rabbits. Tissues included were lung, liver, forestomach, colon, kidney, muscle, and brain. The major adduct iden...

Abstract AlH 3 (PPh ) 2 was synthesized as a stable solid being the first known 1 : alane arylphosphane adduct. Although only weakly intra‐molecularly coordinated, it displays molecular crystal significant inertness against atmospheric humidity and oxygen due to strong steric screening of unit. The compound readily dissociates PPh in solution allowing for its use Lewis acidic reducing agent. Th...

The mechanistic analysis of catalyst-controlled regiodivergent aza-Morita-Baylis-Hillman reactions vinylcyclopentenone is described. DABCO-catalyzed reaction gives the α-adduct exclusively (red reaction) and DMAP-catalyzed produces γ-adduct selectively (blue reaction). revealed that rate-determining step (RDS) α-selective Mannich-type C−C bond formation step, whereas RDS γ-selective seems to be...