The toxic effects of amiodarone on the lung are well recognised, but the rapid onset of those effects, especially in the presence of high inspired oxygen concentrations, are perhaps not adequately appreciated. This may be a potential problem in the Intensive Care Unit (ICU) where amiodarone is frequently used in the treatment of tachydysrhythmias in patients with acute respiratory distress synd...

background: this investigation aimed to evaluate the in vitro scolicidal effects of pistacia khinjuk methanolic extract against protoscoleces of hydatid cysts and its acute toxicity in mice nmri model. methods: protoscoleces were aseptically extracted from sheep livers having hydatid cysts. various concentrations of the essential oil (12.5- 100 mg/ml) were used for 10 to 60 min. viability of pr...

Arsenic toxicity is a global health problem affecting many millions of people. Contamination is caused by arsenic from natural geological sources leaching into aquifers, contaminating drinking water and may also occur from mining and other industrial processes. Arsenic is present as a contaminant in many traditional remedies. Arsenic trioxide is now used to treat acute promyelocytic leukaemia. ...

This study evaluated the safety of rambutan rind extract (RRE) in male Wistar rats. While acute toxicity was evaluated by feeding the rats with single doses of RRE (1000, 2000, 3000, 4000, and 5000 mg/kg) and its sub-chronic toxicity was observed in rats orally administered with RRE (500, 1000, and 2000 mg/kg) daily for 30 days. In acute toxicity study, the LD50 was found to be greater than 500...

In this study, the acute and subchronic toxicity effect of the Syzygium aqueum leaf extract (SA) was evaluated. For the acute toxicity study, a single dose of 2000 mg/kg of the SA was given by oral-gavage to male Sprague-Dawley (SD) rats. The rats were observed for mortality and toxicity signs for 14 days. In the subchronic toxicity study the SA was administered orally at doses of 50, 100, and ...

Patients with acute cocaine poisoning present with life-threatening symptoms involving several organ systems. While the effects of cocaine are myriad, they are the result of a limited number of cocaine-protein interactions, including monoamine transporters, neurotransmitter receptors and voltage-gated ion channels. These primary interactions trigger a cascade of events that ultimately produce t...

We report a case of a female admitted to the emergency department with fever and severe type I acute respiratory failure. After detailed examination, all other potential causes were excluded and the patient was diagnosed with nitrofurantoin-induced acute pulmonary toxicity.

the protective effect of tomato extract and lycopene on acute doxorubicin-induced myocardial toxicity was evaluated in mice. doxorubicin toxicity, induced by a single intraperitoneal injection (15 mg/kg), was revealed by elevated serum cpkmb and histopathological observations. tomato extract (1.2 and 2.4 g/kg, i.p.) and lycopene (1.7 and 3.5 mg/kg, i.p.), prevented the rise in serum cpkmb and a...