In order to evaluate whether immunosuppressive agents such as mycophenolate mofetil (MMF) and azathioprine would differently influence the outcome of the renal transplants, we prospectively analyzed the incidence of acute rejection episodes, cytomegalovirus infection within the first 6 months following renal transplantation and 5 yr graft survival rate after minimizing influences of donor facto...

As we previously reported1•2 documentation of pancreas rejection remains problematic because of the lack of specific and sensitive markers. Since most pancreas transplants are performed simultaneous with a kidney, clinical dysfunction from rejection, documented by an increase in serum creatinine and renal-core biopsy, automatically leads to the treatment of both grafts. Rejections of pancreatic...

Advances in nephrology and pediatric urology have increased the number of children who survive renal disease and become candidates for renal transplantation. Ten years of experience in pediatric renal transplantation are reviewed to determine the rates of patient morbidity and graft survival. Of the 450 renal transplantations performed in Imam Reza Hospital (1989- 1999), fifty-one were don...

Kidney transplantation is the optimal therapy for end-stage kidney disease but requires lifelong immunosuppression. Despite improvements in immunosuppression regimens that have reduced rates of acute transplant rejection, long-term allograft survival remains suboptimal. More than 50% of transplanted kidneys from deceased donors fail within 10 years. In order to improve long-term outcomes, physi...

The introduction of both complement 4d (C4d) staining in renal allograft biopsies and sensitive methods to detect anti-human leukocyte antigen antibodies, such as single antigen bead flow assays, into tissue-typing techniques have shown the importance of antibody-mediated alloimmune response in kidney transplantation. The use of these sensitive methods, combined with the increased number of tra...

Extracorporeal photopheresis is an immunomodulatory technique based on the apoptotic effects of 8methoxypsoralen (8 MOP) and ultraviolet A (UVA) radiation on leukocytes. This technique is widely used in T-cell mediated disorders such as cutaneous T-cell lymphoma, graft-versus-host disease, rheumatoid arthritis and systemic lupus erythematosus. The use of this technique in the prophylaxis of acu...

Acute rejection (AR) in kidney transplant recipients is a major risk factor for chronic allograft failure and reduction in early and long term mean graft survival. New immunosuppressant agents have been developed to reduce the incidence of these episodes (1). Immunobiological drugs such as monoclonal anti-interleukin-2 receptor antibodies have shown promise in this direction; they have a more r...

AFTER cyclosporine (CyA) was introduced as an immunosuppressant in organ transplantation in 1978, the 1-year graft survival rates of patients undergoing liver, kidney, or heart transplantation were improved by about 20%. Since the middle of 1985, CyA-based primary immunosuppression has been used in nearly all transplantation centers in Europe and in the United States. Despite improved 1-year gr...

BACKGROUND The purpose of the study was to describe clinical characteristics and long-term survival of patients undergoing combined heart-kidney transplant in a single center. METHODS We conducted a retrospective analysis of 22 consecutive patients who underwent combined heart-kidney transplant at our institution between 1995 and 2013. Long-term outcomes were analyzed by means of the Kaplan-M...