Background: Acute radiation proctitis (ARP) is a usual adverse effect in patients undergoing pelvic radiotherapy. The symptoms include diarrhea, rectal blood or mucus discharge, fecal urgency and tenesmus with pain. Sucralfate, an aluminum-based salt of sucrose octasulfate, is a cytoprotective agent that forms a coating barrier at injured sites by adhering to mucoproteins. It has been used in t...

OBJECTIVES Quantitative sensory testing (QST) has been used to elucidate the peripheral and central mechanisms that underlie changes in pain sensitivity associated with low back pain (LBP). However, it remains unclear to what degree peripheral and central changes contribute to the generation and maintenance of LBP. The aim of this study was to compare thermal pain sensitivity, measured using QS...

OBJECTIVES To investigate the course and prognosis of shoulder pain in the first 6 months after presentation to the general practitioner. We separately studied patients with acute, subacute and chronic shoulder pain, as duration of symptoms at presentation has been shown to be the strongest predictor of outcome. METHODS A prospective cohort study with 6 months follow-up was carried out in The...

objective(s): our previous studies have shown that mgo nanoparticles (mgo nps) could improve anxiety and reduce pain in animals. in this study, the effect of co administration mgo nps and vitamin c on anxiety like behavior and nociception in postpartum depression (ppd) model were investigated.materials and methods:  female mice (27 ± 3 g) were divided into groups: two control groups, ppd groups...

plaints in the acute care setting. Major causes of acute chest pain include cardiac, gastroesophageal, musculoskeletal, and pulmonary conditions. Because heart disease is the leading cause of death in the United States,1 it is important to diagnose a cardiac etiology in patients presenting with acute chest pain. In addition, noncardiac causes of chest pain may be serious. Conducting a thorough ...

OBJECTIVE There is limited information about the extent to which the association between preoperative and chronic postoperative pain is mediated via pain-on-movement or pain-at-rest. We explored these associations in patients undergoing total hip replacement (THR) and total knee replacement (TKR). METHODS A total of 322 and 316 patients receiving THR and TKR, respectively, were recruited into...

A focused history taking and physical examination directed toward uncovering signs that suggest a serious underlying cause of low back pain are crucial. "Red flags" include pain that lasts more than 6 weeks; pain in persons younger than 18 years or older than 50 years; pain that radiates below the knee; a history of major trauma; poor rectal tone; constitutional symptoms; atypical pain (eg, tha...

Acute pelvic pain, defined as the sudden onset of lower abdominal or pelvic pain lasting less than 3 months [1], is a common urgent clinical presentation. Women frequently present to the emergency department after hours. More than one third of women of reproductive age experience nonmenstrual pelvic pain [2]. Acute pelvic pain can pose a diagnostic challenge because the clinical history, sympto...

A few years ago the prevalent attitude towards acute pain was widespread acceptance as inevitable and frequent indifference to its suboptimal management. However with the dedicated efforts of health care professionals worldwide, pain management is understood to be a fundamental human right and integral to the ethical, patient‐centred and cost‐ effective practice of modern medicine. Management o...