Transient muscle paralysis engendered by a single injection of botulinum toxin A (BTxA) rapidly induces profound focal bone resorption within the medullary cavity of adjacent bones. While initially conceived as a model of mechanical disuse, osteoclastic resorption in this model is disproportionately severe compared with the modest gait defect that is created. Preliminary studies of bone marrow ...

Acute generalized weakness has a wide differential diagnosis that includes neurologic, metabolic, and infectious aetiologies. Acute hypokalaemic paralysis is a rare but treatable cause of acute weakness. We present a 23-year old lady, with history of sudden difficulty getting up from recumbency. Her initial investigations revealed hypokalemia with nonanion gap metabolic acidosis and alkaline ur...

OBJECTIVE IgG and IgA immunocompetence of children with wild poliovirus poliomyelitis and non-polio acute flaccid paralysis. METHODS 932 cases of acute flaccid paralysis, reported in 2008-2009, were tested for presence of polio and non-polio enteroviruses according to the WHO standards. Serum IgA and IgG levels were determined by sandwich ELISA. RESULTS Mean (SD) IgA levels [0.87 (0.62)g/L;...

Bee stings are commonly encountered worldwide. Various manifestations after bee sting have been described. Local reactions are common. Unusually, manifestations like vomiting, diarrhea, dyspnea, generalized edema, acute renal failure, hypotension and collapse may occur. Rarely vasculitis, serum sickness, neuritis and encephalitis have been described which generally develop days to weeks after a...

Acute Kidney Injury in children following bee sting envenomation is rare and survival is hinged on early recognition and prompt appropriate management. This report is aimed at raising awareness among healthcare workers, of one of the systemic effects of massive bee sting and the need to develop sting treatment protocol. A three year old preschooler was attacked by a swarm of bees, receiving ove...

We report a case of severe rapid-onset paralysis in a 28- year-old previously healthy man, necessitating intubation and mechanical ventilation, after a presumed bite or sting. Despite no other systemic manifestations of envenoming, the paralysis rapidly responded to polyvalent snake antivenom. The rapidity and severity of clinical effects make this case most concerning. We outline a differentia...