نتایج جستجو برای: active site pattern
تعداد نتایج: 1079201 فیلتر نتایج به سال:
Among the requirements of a mechatronic system those related to its smart functions are crucial for an effective design. Smartness is associated to the system capability of self–adapting when the operating conditions change and usually it resorts to the action of the control system. The occurrence of the ‘Systems Engineering’ greatly improved a suitable definition of the system smartness, by id...
In this paper, we describe a new approach to managing large image databases which we call active browsing. Active browsing integrates relevance feedback into the browsing environment, so that users can modify the database’s organization to suit the desired task. Our method is based on a similarity pyramid data structure which hierarchically organizes the database so that it can be efficiently b...
Phosphotriesterase catalyzes the hydrolysis of organophosphate nerve agents. Four amino acid residues, located within the active site pocket, were mutated in an effort to ascertain the roles that these groups play in the structure and function of this enzyme. Tryptophan-131 is located at the entrance to the binuclear metal center, and the indole ring is positioned to suggest that it could provi...
The kinetics of charge transfer depend crucially on the dielectric reorganization of the medium. In enzymatic reactions that involve charge transfer, atomic dielectric response of the active site and of its surroundings determines the efficiency of the protein as a catalyst. We report direct spectroscopic measurements of the reorganization energy associated with the dielectric response in the a...
Glucocerebrosidase (GBA) is a lysosomal β-glucosidase that degrades glucosylceramide. Its deficiency results in Gaucher disease (GD). We examined the effects of active site occupancy of GBA on its structural stability. For this, we made use of cyclophellitol-derived activity-based probes (ABPs) that bind irreversibly to the catalytic nucleophile (E340), and for comparison, we used the potent re...
The 11-cis-retinal binding site of rhodopsin is of great interest because it is buried in the membrane but yet must provide an environment for charged amino acids. In addition, the active-site lysine residue must be able to engage in rapid Schiff base formation with 11-cis-retinal at neutral and lower pH values. This requires that this lysine be unprotonated. We have begun to study the environm...
MOTIVATION Finding functionally analogous enzymes based on the local structures of active sites is an important problem. Conventional methods use templates of local structures to search for analogous sites, but their performance depends on the selection of atoms for inclusion in the templates. RESULTS The automatic selection of atoms so that site matches can be discriminated from mismatches. ...
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