BACKGROUND Notch and Wnt pathways are key regulators of intestinal homeostasis and alterations in these pathways may lead to the development of colorectal cancer (CRC). In CRC the Apc/β-catenin genes in the Wnt signaling pathway are frequently mutated and active Notch signaling contributes to tumorigenesis by keeping the epithelial cells in a proliferative state. These pathways are simultaneous...

β-Lactamases are produced by many modern bacteria as a mechanism of resistance toward β-lactam antibiotics, the most common antibiotics in use. β-Lactamases, however, are ancient enzymes that originated billions of years ago. Recently, proteins corresponding to 2- to 3-Gy-old Precambrian nodes in the evolution of Class A β-lactamases have been prepared and shown to be moderately efficient promi...

Background. The anaerobic gut fungi (phylum Neocallimastigomycota) represent a promising source of novel lignocellulolytic enzymes. Here, we report on the cloning, expression, and characterization of a glycoside hydrolase family 39 (GH39) enzyme (Bgxg1) that is highly transcribed by the anaerobic fungus Orpinomycessp. strain C1A under different growth conditions. This represents the first study...

Abstract Background Ceftazidime-avibactam (CAZ-AVI) is a β-lactam/non-β-lactam β-lactamase inhibitor combination that can inhibit class A, C, and some D β-lactamases. Resistance caused by these β-lactamases often results in multidrug-resistance (MDR). This study evaluated the vitro activity of CAZ-AVI comparators against MDR Enterobacterales Pseudomonas aeruginosa isolates collected from patien...

Abstract Organic electrochemistry is a technique that allows for the heterogeneous redox reactions avoiding both use of stoichiometric amounts reagents and resulting formation by-products. In fact, reagent in these electron, which naturally eco-friendly produces no side compounds. It therefore quite obvious can be classified as “green” technology. The this methodology synthesis β-lactams not no...

β-Adrenergic receptors (β-ARs) are G protein-coupled involved in important physiological and pathological processes related to blood pressure cardiac activity. The inhibition of β1-ARs could be beneficial myocardial hypertrophy, ischemia failure. Several carbazole-based compounds have been described as promising β-blockers. Herein, we investigate the capability a carbazole derivative three simp...

Metal-free, molecular iodine-free direct 1,2-difunctionalization of unactivated alkenes has been reported. The sulfonium iodate(i) reagent efficiently promoted the intermolecular vicinal iodo-functionalization of a diverse range of olefins in a stereo and regioselective manner. This method enables the divergent and straightforward preparation of synthetically useful functionalities; β-iodocarbo...

The β-amino carboxylic acid moiety is a key feature of numerous important biologically active compounds. We describe a syn-selective direct Mannich addition reaction that uses α-iodo thioesters and sulfonyl imines and produces β-amino thioesters. Enolate formation is achieved by reductive soft enolization. The products of the reaction provide straightforward access to biologically important β-l...

The stereoselective synthesis of β -amino acids and their derivatives has been an active area of research, due to the importance of β -amino acids in various fields [1]. In particular, non-proteinogenic β -amino α-hydroxy acids are found in many natural products and drugs, for example N-benzoyl-3-phenylisoserine as a side-chain of taxol which has been approved for treatment of ovarian and breas...

β-catenin is a multifunctional protein, acting both as a structural component of the cell adhesion machinery and as a transducer of extracellular signals. Deregulated β-catenin protein expression, due to mutations in the β-catenin gene itself or in its upstream regulator, the adenomatous polyposis coli (APC) gene, is prevalent in colorectal cancer and in several other tumor types, and attests t...