BACKGROUND It was shown earlier that a number of CD207 positive Langerhans cells was lower in basal cell carcinomas than in the normal epidermis. Moreover, benign skin lesions presented a higher number of Langerhans cells when they were compared to malignant tumors. AIM To count Langerhans cells, assessing expression levels of CD1A and CD207 markers in actinic keratosis, basal and squamous ce...

OBJECTIVE Our study aimed to characterize alteration in the immunohistochemical p16 expression in normal oral mucosa and non-neoplastic hyperproliferative disorders (i.e. frictional keratosis and mucosa from smokers). STUDY DESIGN 43 specimen of oral mucosa were examined using immunohistochemistry. RESULTS In normal mucosa, there was strong positive nuclear staining in a proportion of fibro...

I. Background Seborrheic keratoses are common, benign, pigmented epidermal tumors.[1] Many terms such as senile wart, melanoacanthoma, basal cell papilloma, senile keratosis and seborrheic wart have been applied, but seborrheic keratosis is the most widely accepted term. These usually develop after the age of 50 years although occasionally, seen in young adulthood without any sexual predilectio...

Epidermal cells are the first cells to be exposed to environmental genotoxic agents such as ultraviolet and ionizing radiations, which induce DNA double strand breaks (DSB) and activate DNA damage response (DDR) to maintain genomic integrity. Defective DDR can result in genomic instability (GIN) which is considered to be a central aspect of any carcinogenic process. P53-binding protein 1 (53BP1...

Recognized features of the yellow nail syndrome include yellow nails, lymphedema, and pleural effusions. We report a patient with the additional feature of keratosis obturans, which may be a manifestation of this syndrome in the external ear.

BACKGROUND There is limited information on the patterns of use, adherence rates, and factors that impact adherence with topical treatments for actinic keratosis (AK). OBJECTIVES To establish patterns of use and adherence with topical treatments for AK and to identify treatment-related factors that impact on adherence. METHODS A community-based, cross-sectional study was performed using a st...

BACKGROUND Cutaneous horns usually develop on a keratinocytic base with the histopathology on a spectrum ranging from benign keratosis through to invasive squamous cell carcinoma (SCC). Some features of horns are easily identified using dermatoscopy. OBJECTIVE To investigate if specific clinical or dermatoscopy features of horns correlate with the histopathology in the base of the horn. MET...

LM: Lentigo maligna pAK: pigmented actinic keratosis RCM: reflectance confocal microscopy M elanoma on sun-damaged skin, commonly known as lentigo maligna (LM, akin to melanoma in situ) and lentigo maligna melanoma (akin to invasive melanoma), is mostly found on the head and neck of elderly patients. This type of melanoma, particularly when found early, may be difficult to diagnose on clinical ...