conclusions the results of this study indicated that the genes encoding aminoglycoside-modifying enzymes are prevalent in a. baumannii isolates in the study region, which highlighted the necessity of considering preventive measures to control dissemination of these resistance genes. results antimicrobial susceptibility analysis showed that the highest resistance was towards beta−lactam antibiot...

conclusions the rate of carbapenem resistant a. baumannii isolates were high in this study. since, blaoxa-58-like or mbl genes were not detected, it seems that resistance to carbapenems is related to blaoxa-23-like and blaoxa-24-like. moreover, blaoxa-23-like was the most prevalent oxacillinase (oxa) gene. most of the isolates belonged to one of the four dominant genotypes indicating clonal dis...

background: acinetobacter baumannii is an opportunistic and gram-negative coccobacillus. this opportunistic pathogen infectivity, especially in the intensive care units of hospitals is extensive worldwide. due to the incremental pattern of antibiotic resistance, this study was carried out to track the class i, ii and iii integrons in acinetobacter baumannii isolated from hospitalized cases in m...

Sir, The New Delhi metallo-lactamase (NDM), initially reported in Klebsiella pneumoniae and Escherichia coli, is now disseminated worldwide mostly among Enterobacteriaceae [1]. The NDM carbapenemase has also been described in Acinetobacter baumannii, but only in sporadic cases in countries such as China, India, Egypt, Germany, Israel and, more recently, Brazil [1,2]. Noteworthy, recent studies ...

Acinetobacter baumannii: A Dangerous Pathogen Emerges By Peter C. Iwen, PhD, Associate Director, NPHL Acinetobacter baumannii is considered the most common oxidase-negative non-fermenting gramnegative rod encounter in the clinical laboratory [1]. This organism is widely distributed in nature and in the hospital environment and generally considered an opportunistic pathogen in debilitated patien...

Acinetobacter baumannii is a Gram-negative coccobacillus found primarily in hospital settings that has recently emerged as a source of hospital-acquired infections. A. baumannii expresses a variety of virulence factors, including type IV pili, bacterial extracellular appendages often essential for attachment to host cells. Here, we report the high resolution structures of the major pilin subuni...

BACKGROUND The number of reported cases, infected with carbepenem resistant Acinetobacter baumannii (CRAb) and multi-drug resistant (MDR) Acinetobacter species had gradually increased in most PLA general hospital wards from April to June in 2007. OBJECTIVES We have described the investigation of an outbreak of CRAb and MDR Acinetobacter in PLA general hospital, Beijing. The prospective and re...

The adeH and adeS Efflux Pump Genes in Imipenem Colistin-Resistant Acinetobacter baumannii Clinical Isolates

BACKGROUND Bacteria that produce Klebsiella pneumoniae carbapenemases (KPCs) are resistant to broad-spectrum β-lactam antibiotics. The objective of this study was to phenotypically and genotypically characterize the antibiotic susceptibility to carbapenems of 297 isolates recovered from clinical samples obtained from inpatients at 16 hospitals in São Luis (Maranhão, Brazil). METHODS The study...

BACKGROUND Multidrug-resistant (MDR) Acinetobacter spp. acquire antimicrobial agent-resistance genes via class 1 integrons. In this study, integrons were characterized to investigate the antimicrobial resistance mechanisms of MDR Acinetobacter isolates. In addition, the relationship between the integron type and integron-harboring bacterial species was analyzed by using epidemiological typing m...