The ready accessibility of (R)- α -aminoadipic acid by enzymatic cleavage of cephalosporin C (CephC) in the production of 7-aminocephalosporanic acid (7-ACA) on a large scale makes it a favorable chiral pool building block for the synthesis of unusual amino acids. A route for the synthesis of C-5-alkenyl and C-6-alkylidene derivatives of (R)-pipecolic acid is described which utilizes (R)- α -am...

Tujuan riset ini antara lain buat menguji serta menganalisis : 1. Peranan auditor terhadap pelaksanaan good governance di Inspektorat Provinsi Sumatera Utara. 2. Komitmen pimpinan 3. kinerja 4. 5. Pelaksanaan 6. lewat 7. Riset dilasanakan Di Lembaga Utara, Jalan Diponegoro Medan Kantor Gubernur Populasi dalam merupakan pejabat karyawan yang terletak pada jabatan fungsional sebanyak 91 orang. Be...

T here is little debate that unchecked human population growth and the development of " modern " societies are responsible for the current biodiversity crisis. To stop the growing loss of biodiversity, global conservation efforts have mostly focused on creating protected areas free of human influence [1]. But many of these protected areas are also in crisis. In most cases, their long-term viabi...

The selective inhibition of the aspartyl protease renin is of high interest to control hypertension and associated cardiovascular risk factors. Following on preceding contributions, we report herein on the optimization of two series of azaindoles to arrive at potent and non-chiral renin inhibitors. The previously discovered azaindole scaffold was further explored by structure-based drug design ...

[formula: see text] Treatment of vinyl-substituted [2.2.1]- and [2.2.2]-bicyclocarbinols with NaOCl and AcOH provides [3.2.1]- and [3.2.2]-beta-chloro-bicycloketones, respectively. For [2.2.2]-bicycles, these chlorinative ring expansions are particularly efficient and selective.