نتایج جستجو برای: acid ceramidase
تعداد نتایج: 747667 فیلتر نتایج به سال:
RATIONALE Anti-inflammatory and vascular protective actions of adiponectin are well recognized. However, many fundamental questions remain unanswered. OBJECTIVE The current study attempted to identify the adiponectin receptor subtype responsible for adiponectin's vascular protective action and investigate the role of ceramidase activation in adiponectin anti-inflammatory signaling. METHODS ...
Ceramide is important for water retention and permeability barrier functions in the stratum corneum, and plays a key role in the pathogenesis of atopic dermatitis (AD). A Pseudomonas aeruginosa-derived neutral ceramidase (PaCDase) isolated from a patient with AD was shown to effectively degrade ceramide in the presence of Staphylococcus aureus-derived lipids or neutral detergents. However, the ...
A wide range of environmental factors (e.g. UV radiation, pollution) challenges skin homeostasis and its prolonged imbalance accelerates aging. Aged is characterized by presence senescent cells, which have a changed appearance phenotype, accumulate damaged biomolecules simultaneously produce mixture danger signaling molecules negatively affect their microenvironment activate the immune response...
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