Carbonic anhydrase 2 regulates acid-base homeostasis, and recent findings have indicated a correlation between cellular control of acid-base status and the innate defense of the kidney. Mice deficient in carbonic anhydrase 2 (Car2(-/-) mice) have metabolic acidosis, impaired urine acidification, and are deficient in normal intercalated cells. The objective of the present study was to evaluate t...

1. Studies of whole-body balances of non-metabolizable base (NB) and several minerals, and of relevant acid-base quantities in blood and urine, were carried out in two 6-month-old ruminating Holstein X Friesian bull calves fed on fixed rations containing 500 g barley straw/kg diet (group A) to examine the quantitatively important components of the balance of NB and determine the rates of minera...

approved: La'rn J. Weber Acid-base balance in ammoniotelic fish can be accounted for by the concentrations and net flux rates of four generalized independent variables. The physicochemical principles of acid-base chemistry determine the quantitative interaction of acids and bases in an aqueous solution. In a given medium, acid-base balance is the instantaneous net result of input and output rat...

TO THE EDITOR: This debate (1, 4) focused on whether the increase in plasma [lactate] was the sole contributor to the acidosis associated with exercise at sufficiently high intensities to generate increased plasma [lactate ]. It remains puzzling that many physiologists continue to compare plasma “acidbase” status (pH, PCO2, [HCO3 ]) with whole blood (not plasma) measures of [lactate ], thus equ...

There is both in vitro and clinical evidence that high-dose propofol can inhibit mitochondrial respiration, resulting in metabolic acidosis. The purpose of this study was to evaluate the effects of propofol anesthesia on the acid-base status in neurosurgical patients with large amount of normal saline administration. Thirty patients undergoing clipping of cerebral aneurysm were randomly assigne...

Objective: To find out the pattern of acid base abnormalities in critically ill patients in a tertiary care health facility. Study Design: A descriptive study. Place and Duration of Study: The study was carried out in the department of pathology, Combined Military Hospital Kharian from January 2013 to June 2013. Patients and Methods: Two hundred and fifty patients suffering from various disease...

A description of the acid-base status of arterial blood includes three values : pH, carbon dioxide tension (pC0,) and base excess (BE). pH, normally about 7.40 (7.36 to 7.42), changes by changing pC0, as well as by accumulation of non-volatile acid or base. The p H value is practically always determined directly by means of the glass electrode. pC02, normally about 40 mm Hg (33 to 47), is inver...

background: substitution of arterial with venous blood samples to estimate blood gas status is highly preferable due to practical and safety concerns. numerous studies support the substitution of arterial by venous blood samples, reporting strong correlations between arterial and venous values. this study further investigated the predictive ability of venous blood samples for arterial acid-base...