The development of chronic complications of type 2 Diabetes Mellitus can cause premature death mainly via cardiovascular disease and other chronic complications. It is known from previous studies that Acetylcholinesterase activity of the erythrocyte cell membrane increases in Diabetic patients. High levels of Acetylcholinesterase enzyme concentration can lead to a decrease in the levels of Acet...

Marigold (Calendula officinalis L.) is one of the most common and widespread plants used medicinally all over the world. The present study aimed to evaluate the anti-acetylcholinesterase activity of marigold flowers, detect the compounds responsible and perform chemical analysis of marigold commercial products. Analysis of 23 varieties of C. officinalis flowers introduced into Siberia allowed u...

Sponges, ubiquitously occurring organisms, have many characteristics that indicate their potential as biomonitors. Since it is very important to find the most wide range of organisms that can act as early warners of pollution, we investigated the presence of the biomarker acetylcholinesterase in the cosmopolitan sponge Cliona celata Grant, 1826. Specimens of C. celata were collected from pre-se...

Some embryos of Ciona intestinalis which were permanently cleavage-arrested with cytochalasin B at the 1-cell, 4-cell, or 8-cell stages produced, after 12 or 16 h of development time (18 degrees C), a level of muscle acetylcholinesterase activity equal to that found in normal early and later larval stage embryos of the same age. Enzyme activity was measured quantitatively in single whole embryo...

Addition of acetylcholine to growing cultures of mouse neuroblastoma cells induced a 37-fold increase in the specific activity of acetylcholinesterase (EC 3.1.1.7). Morphological changes, consisting of neurite-extensions, were also observed during the logarithmic phase of growth of cells stimulated with acetylcholine. A histochemical procedure for localization of acetylcholinesterase was used w...

The antioxidant and acetylcholinesterase inhibitory potential of methanol extract from Arnica montana cultivated in Bulgaria was evaluated. For the determination of antioxidant activity 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) di-ammonium salt (ABTS) free radicals, and ferric reducing antioxidant power (FRAP) assay were used. Modified Ellman’s...

The cholinergic hypothesis of Alzheimer's disease (AD) has provided the rationale for the current pharmaco-therapy of this disease, in an attempt to reduce the cognitive decline caused by cholinergic deficits. Nevertheless, the search for potent and long-acting acetylcholinesterase (AChE) inhibitors that exert minimal side effects in AD patients is still ongoing. AChE inhibitors are currently t...

OBJECTIVES Alzheimer's disease (AD) as progressive cognitive decline and the most common form of dementia is due to degeneration of the cholinergic neurons in the brain. Therefore, administration of the acetylcholinesterase (AChE) inhibitors such as donepezil is the first choice for treatment of the AD. In the present study, we focused on the synthesis and anti-cholinesterase evaluation of new ...

The plant Cardaria draba (L.) Desv. subsp. (Brassicaceae), is traditionally used for various ailments in different cultures. We investigated solvent extracts such as methanol, ethanol, and water obtained from flowers, leaves, stems, roots of C. their chemical composition, well antioxidant enzyme inhibition activities acetylcholinesterase (AChE), butyrylcholinesterase (BChE), ?-glucosidase, ?-am...

Background Traditionally, the plant was used for various diseases, including neuronal disorders. To evaluate neuroprotective activity of Hibiscus vitifolius L. against Colchicine induced Alzheimer’s disease in rat model. Method Neuroprotective carried out by on Sprague-Dawley rats. cerebrum colchicine lesion. The behavioural assessments such as locomotor activity, spatial navigation task, open ...