PURPOSE To investigate the role of ERK1/2 and RhoA/ROCK intracellular pathways in the modification of corneal re-epithelialization when stimulated by the diadenosine polyphosphates Ap(4)A and Ap(3)A. METHODS In wounded confluent SIRC (Statens Seruminstitut rabbit cornea) cell monolayers and in the presence or absence of Ap(4)A or Ap(3)A 100 microM, a battery of P2 receptor antagonists and inh...

Catheter ablation for septal accessory pathways is occasionally associated with complications, such as atrioventricular block, since the septal region is a complex anatomical structure containing the atrioventricular conduction system. Therefore, we designed a signal separator composed of an inductance-capacitance network with which the local electrogram at the ablation site could be continuous...

The cost of definitive therapy was compared in 25 patients who underwent radiofrequency catheter ablation of accessory pathways in 1990 and 25 patients who underwent surgical ablation of accessory pathways in 1989. In the radiofrequency group, 23 of 25 patients had a single accessory pathway and the remaining 2 patients each had 2 accessory pathways. In the surgical group, 20 patients had a sin...

The etiology of pediatric hypertrophic cardiomyopathy (HCM) is varied. Ventricular preexcitation (VPe) well recognized, yet little known regarding the specific etiology, and accessory pathways (AP) characteristics. Define HCM in patients with VPe characteristics responsible APs. Retrospective cohort study <21 years age HCM/VPe from 2000-22. was defined as sarcomeric/non-sarcomeric (isolated HCM...

fundamental observations about cardiac pathophysiology. The purpose of this editorial comment is to expand the findings covered in that review to demonstrate how clinical investigators have applied those advances in electrocardiography toward an understanding of the physiology of cardiac arrhythmias (2–4). This knowledge has enabled the practicing cardiologist, armed with no more than a pair of...