histone deacetylases (hdacs) are the enzymes causing deacetylation of histone and non-histone substrates. histone deacetylase inhibitors (hdis) are a family of drugs eliminating the effect of hdacs in malignant cells via inhibition of hdacs. due to extensive effects upon gene expression through interference with fusion genes and transcription factors, hdacs cause proliferation and migration of ...

background: central renin angiotensin system has an important role on the cerebral microcirculation and metabolism. our previous work showed that inhibition of angiotensin converting enzyme (ace) activity prior to induction of ischemia protected the brain from severe ischemia/reperfusion (i/r) injuries. this study evaluated the impacts of post-ischemic inhibition of ace, enalapril, on brain inf...

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background: considering the increasing incidence of coronary artery stenosis and its related complications, the importance of its etiology and inconsistent reports we aimed to determine the relationship between oxysterol, serum levels and severity of coronary atherosclerosis and effect of statins on oxysterol.  methods: a total of 85 patients referred to taleghani hospital, tehran, iran during ...

human alpha 1-antitrypsin (aat) cdna was obtained from hepg2 cell lines. after pcr and construction of expression vector ppiczα-aat, human aat was expressed in the yeast pichia pastoris (p.pastoris) in a secretary manner and under the control of inducible alcohol oxidase 1 (aox1) promoter. the amount of aat protein in medium was measured as 60 mg/l 72 hr after induction with methanol. results i...

gastro-esophageal reflux disease (gerd) regularly occurs when stomach acid moves up from the stomach into the esophagus. gerd might be associated with chronic asthma symptoms such as coughing and breathlessness. according to several studies on children and adults, gerd is proven to have a close relationship with asthma.  medication treatment via proton-pump inhibitors (ppis), such as omeprazole,...

sodium-glucose co-transporter 2 (sglt2) inhibitors are a new glucose-lowering therapy for t2dm with documented benefits on blood glucose, hypertension, weight reduction and long term cardiovascular benefit. they have an inherent osmotic diuretic effect and lead to some volume loss and possible dehydration. there is some concern about the safety of using sglt2 inhibitors in muslim type 2 diabete...