Several new oral drugs have been approved for the management of type II diabetes. Metformin is an "antihyperglycemic agent" that decreases hepatic glucose production and improves insulin sensitivity. It may be used as monotherapy or in combination with a sulfonylurea. Acarbose slows carbohydrate absorption after a meal, giving endogenous or injected insulin more time to respond to ingested gluc...

The 1,4-alpha-glucosidase inhibitor. Acarbose, when injected intraperitoneally disturbs liver lysosome metabolism, causing distinct and persistent inhibition of the enzymes and acute disturbances of lysosomal glycogen metabolism. A feedback control mechanism appears to operate, affecting cytosolic carbohydrate metabolism. A model is suggested for the adult form of lysosomal storage disease. The...

Trigonella foenum graecum (Fenugreek) is a popular herb widely used for culinary and pharmaceutical purposes. The seeds of the plant have been intensively studied, as they exhibit plenty pharmacological properties. objective current research was to investigate hypoglycemic effect fenugreek in vitro vivo. Aqueous (Aq. ex) ethyl acetate (ETAC. extracts were prepared from grinded seeds. α-amylase ...

Sir—Jean-Louis Chiasson and colleagues (June 15, p 2072) report that after a mean follow-up of 33 years, patients with impaired glucose tolerance (IGT) receiving acarbose, an α-glucosidase inhibitor, less frequently developed diabetes and more frequently showed a reversion to normal glucose tolerance than did patients assigned placebo. These conclusions could be used to delay development of typ...

keywords: Postprandial hyperglycaemia (PPHG), Alpha glucosidase inhibitors (αGI) ABSTRACT Diabetes Mellitus (DM) is a morbid disease worldwide, with increasing incidence as time passes. It has macro-vascular and micro-vascular complications. The main cause of these complications is poorly controlled postprandial hyperglycaemia. Alpha glucosidase inhibitors, namely acarbose, voglibose and miglit...