The development of nonhormonal treatment of pemphigus vulgaris (PV) has been hampered by a lack of clear understanding of the mechanisms leading to keratinocyte (KC) detachment and death in pemphigus. In this study, we sought to identify changes in the vital mitochondrial functions in KCs treated with the sera from PV patients and healthy donors. PV sera significantly increased proton leakage f...

Vol. 29, No. 5, 2017 657 Received September 9, 2016, Accepted for publication October 10, 2016 Corresponding author: Soyun Cho, Department of Dermatology, SMG-SNU Boramae Medical Center, 20 Boramae-ro 5-gil, Dongjak-gu, Seoul 07061, Korea. Tel: 82-2-870-2381, Fax: 82-2-870-3866, E-mail: [email protected] This is an Open Access article distributed under the terms of the Creative Commons Attributio...

After so many years of learning about the epidemiology, nature, diagnosis and management of the pemphigus group and other bullous dermatoses at University Department of Dermatology and Venereology, Zagreb University Hospital Center and School of Medicine, it was wonderful to discover – from the oral presentation entitled “Bullöse Dermatosen 2007” held by Prof. Michael Hertl in Graz (Austria) at...

BACKGROUND Darier disease (DD) and Hailey-Hailey disease (HHD) are autosomal dominantly inherited skin disorders that histologically share the characteristics of suprabasal separation and acantholysis of epidermal keratinocytes. Various mutations in the DD gene (ATP2A2) and the HHD gene (ATP2C1) (respectively encoding the calcium pumps of the sarco/endoplasmic reticulum and the Golgi apparatus)...

Pemphigus vulgaris (PV) is a mucocutaneous blistering disease characterized by IgG autoantibodies against the stratified squamous epithelium. Current understanding of PV pathophysiology does not explain the mechanism of acantholysis in patients lacking desmoglein antibodies, which justifies a search for novel targets of pemphigus autoimmunity. We tested 264 pemphigus and 138 normal control sera...

BACKGROUND Pemphigus vulgaris (PV) is a blistering autoimmune disease characterized by IgG autoantibodies against desmoglein 3. Nitric oxide synthases (NOS) may contribute to the increase of inflammation in tissues by the generation of nitrotyrosine residues (NTR). OBJECTIVES To investigate whether the production of NTR mediated by NOS may participate in the development of inflammation and ac...

From the Division of Immunodermatology, Department of Dermatology, Northwestern University Medical School, Chicagoa; the Department of Dermatology, Kurume University School of Medicineb; the Department of Dermatology, Keio University School of Medicine, Tokyoc; and the Medicine Service, Section of Dermatology, Lakeside Division, Veterans Affairs Chicago Health Care System.d Supported by a Clini...

Visceral dissemination of varicella zoster virus (VZV) may follow cutaneous infection in immunocompromized patients (e.g. bone marrow transplant recipients) [1]. However, involvement of the upper gastrointestinal tract is rare [1–4]. An 81-year-old man underwent upper endoscopy for heartburn, nausea, and vomiting. There was no prior history of clinically overt immunodeficiency. Endoscopy reveal...

A dental curing light is a piece of dental tool that is used for the hardening of light cure composites. Many studies have shown these lights induce changes in DNA, mitosis and mitochondria through free radicals production. Light emitting diode (LED) are most commonly used and claim less hazards to the adjacent soft tissues. Current study was therefore designed to observe the morphological chan...