We describe an interesting case of severe asthma who was not showing satisfactory response to standard treatment. Investigations revealed him to be suffering from allergic bronchopulmonary aspergillosis (ABPA). After starting systemic steroids he showed marked improvement initially only to have recurrent symptoms within a year. He was investigated further and found to have chronic pulmonary asp...

Allergic bronchopulmonary aspergillosis (ABPA) is a pulmonary disease that results from a hypersensitivity response to Aspergillus fumigatus [1]. It occurs in asthmatic and cystic fibrosis (CF) patients, with a prevalence among CF patients recently estimated at 7.8% [1]. The natural course is characterised by acute exacerbations, which can be life-threatening [2], and progressive, irreversible,...

Despite being recognized as a distinct clinical entity nearly 70 years ago, allergic bronchopulmonary aspergillosis/mycosis (ABPA), which is what we would today—with our vastly greater understanding of pathobiology—term an asthma endotype,1Lötvall J. Akdis C.A. Bacharier L.B. Bjermer L. Casale T.B. Custovic A. et al.Asthma endotypes: new approach to classification disease entities within the sy...

macrocyclic structure as postulated by the authors; nevertheless this hypothesis must not be rejected and should always be checked. Thus, all mild to severe adverse hypersensitivity reactions should be accurately documented with most of the available gadolinium in order to determine cross reactivities. This is all the more important since challenge with another gadolinium agent giving negative ...

The current standards of care for allergic bronchopulmonary aspergillosis in patients with cystic fibrosis are presented. Recent studies have increased understanding of the inflammatory process that occurs in cystic fibrosis patients with allergic bronchopulmonary aspergillosis. This has resulted in more precise diagnostic criteria that facilitate more timely diagnosis and treatment of ABPA in ...

BACKGROUND Aspergillus is a ubiquitous fungus responsible for allergic as well as saprophytic and invasive manifestations depending on host's immune status. The following case report demonstrates progression of allergic manifestations of Aspergillus to its invasive form in an individual with decreasing immunity. This can lead to uncertainties in diagnosis and management. CASE PRESENTATION A 2...

INTRODUCTION The coexistence of potentially aggravating processes is common in asthmatics, particularly in patients with difficult control. The primary aim of this study is to ascertain whether comorbidity id more common in uncontrolled patients. As a secondary aim, we propose to evaluate the correlation between the asthma control test (ACT) and the fraction of exhaled nitric oxide (FENO). PA...