1 Family Health International, Durham, North Carolina, United States of America. Send correspondence to: Dawn S. Chin-Quee, Family Health International, 2224 E NC 54, Durham, NC 27713, United States of America; telephone: (919) 544-7040, ext. 473; fax: (919) 5447261; e-mail: [email protected] Despite government-sponsored efforts to develop, disseminate, and institutionalize national family pla...

We have investigated the effect of a series of steroidal oestrogen antagonists, related to ICI 164,384, on the DNA binding activity of mouse oestrogen receptors expressed in insect cells. The analogues possess different side chains at the 7-position of the B ring in the steroid. Inhibition was observed when the length of the side-chain was 15-16 carbon atoms but not 10 or 20 carbon atoms and on...

The chemotherapeutic study of a limited series of steroidal sapogenins from several endemic species of the flora of the Canary Islands is presented here. On the whole, they possess a very weak antibacterial activity, a slight antifungal effect and one of them, vespertilin, displays interesting cytostatic activity (ID50 = 5 micrograms/ml). A pharmacodynamic screening carried out on this product ...

Gokshur is one of the plant used in Ayurveda.The plant has diuretic activity.Brihat gokshur and Laghu gokshur are the plants used under the mishrak varga Dashmoola. Both the varieties contains sapogenins,tannins,glycoside etc.. chemical constituents. Among these steroidal saponin is the main active principle which is responsible for the diuretic activity of the plant. The present research work ...

Two new steroidal saponins, named drangustosides A-B (1-2), together with eight known compounds were isolated and characterized from the MeOH extract of Dracaena angustifolia Roxb. The structures of compounds were assigned based on 1D and 2D NMR spectroscopic analyses, including HMQC, HMBC, and NOESY. Compounds 1 and 2 showed anti-inflammatory activity by superoxide generation and elastase rele...

The extracts of the stem bark of Calophyllum soulattri gave a new pyranocoumarin, soulamarin (1), together with five other xanthones caloxanthone B (2), caloxanthone C (3), macluraxanthone (4), trapezifolixanthone (5) and brasixanthone B (6) one common triterpene, friedelin (7), and the steroidal triterpene stigmasterol (8). The structures of these compounds were established based on spectral e...

Amniocentesis and the instillation of various abortifacients has become increasingly popular as a simple and acceptable method for mid-trimester abortions. Experience gained from large abortion series and many clinical trials has shown that, if correctly used in properly selected cases, hypertonic saline and prosta· glandins (PG) are useful and effective drugs to terminate late first trimester ...

OBJECTIVE To compare efficacy of 2 commercial ovine Campylobacter vaccines and an experimental bacterin in guinea pigs following IP inoculation with Campylobacter jejuni IA3902. ANIMALS 51 female guinea pigs. PROCEDURES Pregnant and nonpregnant animals were randomly assigned to 1 of 4 treatment groups and administered a commercial Campylobacter vaccine labeled for prevention of campylobacte...