The Bcl-2 homology 3-only protein Bid is an important mediator of death receptor-induced apoptosis. Recent reports and this study suggest that Bid may also mediate genotoxic drug-induced apoptosis of various human cancer cells. Here, we characterized the role of Bid and the mechanism of Bid activation during oxaliplatin-induced apoptosis of HeLa cervical cancer cells. Small hairpin RNA-mediated...

JNK contributes to TNF␣-mediated apoptosis remains Molecular and Cellular Biology to be addressed. Baylor College of Medicine The intrinsic apoptotic pathway is the result of activa-Houston, Texas 70030 tion of mitochondria-mediated cell death events, including changes in mitochondrial membrane permeability and subsequent release of proapoptotic factors in-Summary volved in various aspects of a...

Antibody F(ab')2 fragments derived from the sera of four patients with histology-proven chronic Chagas myocarditis [cF(ab')2]-complexed antibody F(ab')2 fragments of children with acute Trypanosoma cruzi infection [aF(ab')2] in significantly higher molar ratios than those measured with F(ab')2 antibody fragments of normal subjects [nF(ab')2] from nonendemic areas (p less than 0.05). Anti-idioty...

It typically occurs as an alteration product at the contact between felsic and mafic or ultramafic rocks such as pyroxenites and dunites. It also occurs in carbonatites and metamorphosed magenesium rich limestone. Associated mineral phases include: corundum, apatite, serpentine and talc. It occurs interlayered with chlorite, biotite and phlogopite.[2] Vermiculite Wikipedia, the free encyclopedi...

PURPOSE To determine whether the FAS-mediated apoptosis pathway becomes activated in the retina after retinal detachment and to investigate the temporal relationship between the activation of the FAS-pathway and the intrinsic apoptosis pathway involving caspase-9 and cytochrome c. METHODS Experimental retinal detachments were created in Brown-Norway rats by injecting 10% hyaluronic acid into ...

Osmium isotope compositions and concentrations of Re, platinum group elements (PGE), and Au were determined for host peridotites (serpentinites and harzburgites) and hydrothermally altered ultramafic wall rocks associated with Mother Lode-type hydrothermal gold-quartz vein mineralization in the Alleghany district, California. The host peridotites have Os isotope compositions and Re, PGE, and Au...

Soil microorganisms play key roles in ecosystem functioning and are known to be influenced by biotic and abiotic factors, such as plant cover or edaphic parameters. New Caledonia, a biodiversity hotspot located in the southwest Pacific, is one-third covered by ultramafic substrates. These types of soils are notably characterised by low nutrient content and high heavy metal concentrations. Ultra...

22 homosexual or narcotic addict patients at risk for acquired immunodeficiency syndrome (AIDS) or with AIDS, were studied for the presence of antiimmunoglobulin antibodies and circulating immune complexes (20 were thrombocytopenic, 6 had AIDS). Circulating immune complex levels were 10-fold higher than levels in normal subjects. IgG anti-F(ab')2 antibodies were noted in homosexual as well as n...

Cells/tissues are then lysed and the Ab is added. Recovery of the Ab‐ t‐X complex is then done mostly using a capture resin made of ProteinA‐coated beads which bind the Fc portion of the Ab. However other systems exist which rely on other types of affinity interactions, i.e. biotinylation (strept)avidin systems or (His)6  Ni2+ columns etc. It is important to note that, several interactions (o...