The objective of the present study was to investigate whether cyclooxygenase-2 (COX-2) is associated with malignancy, and to investigate its molecular mechanisms in human lung cancer tumor malignancy. The present study used RNA interference (RNAi) methodology and celecoxib, a COX-2 inhibitor, to investigate the effect of COX-2 knockdown on the proliferation and invasion abilities of lung cancer...

Abstract Photodynamic therapy (PDT), as a clinical treatment, can remove malignant cells upon laser irradiation by selective uptake of photosensitizer (PS). The relative contribution these antitumor effects depends largely on the dose and PS. In this study, C 3 N 4 @RP was chosen candidate for studies different cancer cells. has been proved to possess excellent properties, including absorption ...

Benzo(a)pyrene (BaP), an important toxic component of cigarette smoke, can cause lung cancer and lead to the progression of lung cancer. In the present study, we investigated the effect of BaP on the migration of lung adenocarcinoma A549 cells. BaP (1 µM) promoted the migration of A549 cells in a time-dependent manner and upregulated the expression of the Twist family BHLH transcription factor ...

BACKGROUND AND OBJECTIVE Curcumin, a natural compound, is derived from the rthizom of Curcuma longa. In vitro and in vivo preclinical studies have shown its anti-inflammatory, antioxidant, anticancer activities and so on. miR-186*, which was found by microarray technology, was highly expressed in lung carcinoma cells A549/DDP. The aim of this study is to illustrate whether Curcumin could promot...

Pulmonary research requires models that represent the physiology of alveolar epithelium but concerns with reproducibility, consistency and the technical and ethical challenges of using primary or stem cells has resulted in widespread use of continuous cancer or other immortalized cell lines. The A549 'alveolar' cell line has been available for over four decades but there is an inconsistent view...

Lung cancer is the leading cause of cancer-related mortality worldwide. Most lung patients with brain metastases have very poor prognosis. The most common type from human adenocarcinoma. Although cyclin-dependent kinase (CDK) 9 has an established pathogenic role in various cancers, its function metastasis remains poorly defined. We A549 BrM3 cell line a parental (K-rasG12S). And investigated ex...

Since lung cancer is the leading cause of cancer-related death worldwide, research being conducted to discover anticancer agents as its treatment. Eleutherine bulbosa, a Dayak folklore medicine, exhibited effects against several cells; however, potency cells has not been explored yet. This study aims determine E. bulbosa bulbs (A549) using 2D and 3D culture models, well active compounds gas chr...

The non-small cell lung cancer is a common malignancy with high metastasis capacity. brain the primary site for patients unclear mechanism. Here, in this study, we hypothesized an innovative signaling cascade disorder and systematically investigated underlying Their differentially gene expression analysis was based on 13 conventional nonsmall 15 respectively. line, adenocarcinomic human alveola...

The purpose of the present study is to observe the role of volume-sensitive Cl(-) channels in carboplatin-induced apoptosis in the human lung adenocarcinoma cell line A549 cells. Using patch clamp and apoptosis assays, we found that A549 cells underwent the process of apoptotic volume decrease (AVD) and apoptosis when treated with carboplatin or staurosporine (STS). This AVD and apoptosis proce...

Distal metastasis is the major cause of death for the vast majority of lung cancer patients. Many extracellular matrix (ECM)-related molecules are proposed to be associated with the migration and invasion of cancer cells. FRAS1 encodes an ECM protein, however, little is known about its function on tumorigenesis and metastasis of lung cancer. In this work, FRAS1 was silenced by shRNA in non-smal...