Nucleotide repeat expansions can elicit neurodegeneration as RNA by sequestering specific RNA-binding proteins, preventing them from performing their normal functions. Conversely, mutations in RNA-binding proteins can trigger neurodegeneration at least partly by altering RNA metabolism. In Fragile X-associated tremor/ataxia syndrome (FXTAS), a CGG repeat expansion in the 5'UTR of the fragile X ...

biofertilizers are natural inputs that can be applied as complement or substituent of chemical fertilizers in sustainable agriculture. effects of n and p bio- and chemical fertilizers on growth indices of maize (zea mays l.) was studied on 2008 in shushtar, iran, based an as a factorial experiment based on completely randomized block design with three replications. treatments consisted four lev...

After the mining of mineral resource, mineland resources utilization became increasingly complicated. Soil and planting information can be used as the indicators to evaluate mineland reclamation level. In order to obtain the soil and planting information in real time, a CDMA-based soil-quality monitoring system was developed to wirelessly monitor air/soil environment and plant image in remote o...

based on spi and rdi indices, changes in droughts in the semi-arid areas of west golestan province was assessed in the gis environment by incorporating data from hashemabad synoptic station and 11 climatic stations. after evaluating the ability of lars-wg5 in the simulation period (1984-2010), downscaling of hadcm3, ipcm, and gfc models was done as a group under scenarios of a1b, a2 and b1 to e...

BACKGROUND Lidocaine can promote the apoptosis of eosinophils, which is normally delayed by IL-5; it has a good effect on serious steroid resistant asthma (SRA). The study aimed to explore the effect of nebulized lidocaine inhalation on asthma. METHODS It was a randomized, double-blind, placebo-controlled and prospective study. A total of 36 patients with acute asthma were divided into groups...

BACKGROUND D2 dopamine receptor gene has been reported to be one of the most relevant candidate genes in schizophrenia. In this study, we investigated the association between TaqIA and TaqIB dopamine D2 receptor polymorphisms and psychopathology of schizophrenia. METHODS The study subjects were 38 acutely exacerbated schizophrenic patients who were all Iranian descent. The control population ...

Human papillomavirus type 16 (HPV-16) 5'-splice site SD3632 is used exclusively to produce late L1 mRNAs. We identified a 34-nt splicing inhibitory element located immediately upstream of HPV-16 late 5'-splice site SD3632. Two AUAGUA motifs located in these 34 nt inhibited SD3632. Two nucleotide substitutions in each of the HPV-16 specific AUAGUA motifs alleviated splicing inhibition and induce...

to study the effect of planting pattern and water quantity on potato yields under drip irrigation, this research was conducted using a split plot based on a randomized complete block design with four replications in three regions (mashhad, ardebil and damavand, iran) during 2003-2004. nine treatments were used. the main-plots were three levels of irrigation: 100%(i1), 80%(i2), and 60%(i3) of cr...

The nematicidal activity of the fungicide ethazole was studied under greenhouse conditions in which a nematode-infested, Norfolk sandy loam was planted to cotton (var. = 'Rowden'). At planting time, the fungicide was incorporated in the soil at rates of 0-100 mg/kg soil. When assayed 4 weeks after planting, plant-parasitic nematodes in soil and roots occurred in decreasing numbers with increasi...