Acquired aortic stenosis, when severe, often gives rise to pulsus alternans.' Other relatively common causes for pulsus alternans include hypertensive heart disease, coronary artery disease, syphilitic heart disease and cardi~myopathy.~ When pulsus alternans is present, the clinician can usually appreciate it through the use of a sphygmomanometer, in which case when the cuff is infiated to near...

Many economic and social networks share two common organizing features: (1) a coreperiphery structure; (2) positive correlation between network centrality and payo¤s. In this paper, we build a model of network formation where these features emerge endogenously. In our model, the unique equilibrium network architecture is a periphery-sponsored star. In this equilibrium, one player, the center, m...

In several crops, the water deficit is perhaps the main limiting factor in the search for high yields. The objective of this study was to evaluate the phenotypic stability of maize hybrids in environments with and without water restriction using the analytical factor (AF) approach. We evaluated 171 maize hybrids in 14 environments, divided into environments with (A1, A2, A3, A4, A5, A6, and A7)...

We present a model of network formation where entering nodes find other nodes to link to both completely at random and through search of the neighborhoods of these randomly met nodes. We show that this model exhibits the full spectrum of features that have been found to characterize large socially generated networks. Moreover, we derive the distribution of degree (number of links) across nodes,...

Selenocysteine (Sec) is the 21st amino acid in translation. Sec tRNA (tRNA(Sec)) has an anticodon complementary to the UGA codon. We solved the crystal structure of human tRNA(Sec). tRNA(Sec) has a 9-bp acceptor stem and a 4-bp T stem, in contrast with the 7-bp acceptor stem and the 5-bp T stem in the canonical tRNAs. The acceptor stem is kinked between the U6:U67 and G7:C66 base pairs, leading...

11 This paper proposes a new statistical technique for deciding which of two theories is better supported 12 by a given set of data while allowing for the possibility of drawing no conclusion at all. Procedurally 13 similar to the classical hypothesis test, the proposed technique features three, as opposed to two, 14 mutually exclusive data classifications: reject the null, reject the alternati...

Human insulin synthesized from A and B chains separately produced in Escherichia coli from cloned synthetic genes (prepared by the Eli Lilly Research Laboratories, Indianapolis, IN) was characterized by examining its interaction with human cultured lymphocytes, human circulating erythrocytes in vitro, and isolated rat fat cells. The binding behavior of the biosynthetic insulin with human cells ...

We study the long-run stability of trade networks in a two-sided economy of agents labelled men and women. Each agent desires relationships with the other type, but having multiple partners is costly. This cost-benefit trade-off results in each agent having a single-peaked utility over the number of partners—the volume of trade—, the peak being greater for men than for women. We propose a stoch...

Throughout the vertebrate lineage, dopaminergic neurons form important neuromodulatory systems that influence motor behavior, mood, cognition, and physiology. Studies in mammals have established that dopaminergic neurons often use γ-aminobutyric acid (GABA) or glutamatergic cotransmission during development and physiological function. Here, we analyze vglut2, gad1b and gad2 expression in combin...

This examination of the role and potential for replication in economics points out the paucity of both pure replication – checking on others’ published papers using their data – and scientific replication – using data representing different populations in one’s own work or in a comment. Several controversies in empirical economics are used to illustrate how and how not to behave when replicatin...