A role for intracellular ROS production has been recently implicated in the pathogenesis and progression of a wide variety of neoplasias. ROS sources, such as NAD(P)H oxidase (Nox) complexes, are frequently activated in AML (acute myeloid leukemia) blasts and strongly contribute to their proliferation, survival, and drug resistance. Myelodysplastic syndromes (MDS) comprise a heterogeneous group...

We report a case of Miller-Dieker syndrome (MDS) owing to an unbalanced rearrangement of a familial pericentric inversion of chromosome 17 (inv(17) (p13.3q25.1)). In addition to lissencephaly and the facial features of MDS, the affected child had other congenital malformations consistent with distal 17q duplication. Initial cytogenetic analysis failed to show any abnormality and fluorescence in...

Methods Thirty-three sampling sites were located from 0 to 2400 m a.s.l. on Crete, and sampled using pitfall traps. Material from the high-activity period of Gnaphosidae (mid-spring to mid-autumn) was analysed. Sampling sites were divided into five altitudinal zones of 500 m each. Statistical analysis involved univariate statistics (anova) and multivariate statistics, such as multidimensional s...

We consider a fault-tolerant distributed storage system that protects data on k disks using a systematic linear (n, k) MDS code. In such a system, updates to data blocks require corresponding updates to check blocks. Concurrent fault-prone access by multiple writers can drive the system into an inconsistent state with reduced tolerance for disk failures. We show tight bounds on the erasure reco...