Receptors for somatostatin (SST) (SSTR) are expressed on various tumor cells as well as on activated lymphocytes. Previous data have shown that 99mTc-P829 binds with high affinity to many different types of tumor cells as well as to leukocytes via the human hSSTR2, hSSTR3, and hSSTR5 target receptors. Consequently, 99mTc-P829 was successfully introduced as a peptide tracer for tumor imaging. In...

UNLABELLED 99mTc-methoxyisobutylisonitrile (99mTc-MIBI) has been suggested as a tracer for the scintigraphic detection of multidrug resistance (MDR). The aim of this study was to compare MDR characteristics in vitro and in vivo by immunohistochemic and functional uptake assays in established tumor cell lines cultured and grown in severe combined immunodeficient (SCID) mice. METHODS The presen...

In 1987, we started octreotide receptor scintigraphy in humans. After a few years of using the radioiodinated [Tyrs]-octreotide,' we switched to [lllIn-DTPA-~-Phe*]octreotide, which has many advantages over the radioiodinated Patients with various forms of cancer, both classically known as neuroendocrine and nonendocrine, have been inve~tigated.~ The application of these new peptide-receptor ag...

We report the case of a female patient who had a neuroendocrine tumor in the pancreatic tail. Followup using (68)Ga DOTA-d-Phe(1)-Tyr(3)-octreotide (DOTATOC) positron-emission tomography (PET)/computed tomography (CT) detected a round, well-circumscribed nodular mass that exhibited positive somatostatin receptors. This finding was highly suggestive of an accessory spleen; however, due to the sl...