After exposure to 2 mg/L (14)C-labelled KRM-1648 (a new broad-spectrum benzoxazinorifamycin antibiotic) for 5 min, a steady-state concentration of 31.3 +/- 3 ng/mg cells KRM-1648 and 12. 6 +/- 0.3 ng/mg cells KRM-1648 was accumulated by wild-type antibiotic-susceptible Mycobacterium aurum (A+) and Mycobacterium tuberculosis (H37Rv), respectively. However, 2 mg/L KRM-1648 was bactericidal for M....

Objective(s): Drug delivery via mucosal routes has been confirmed to be effective in inducing strong immune responses. Liposomes could enhance immune responses and mucoadhesive potentials, make them useful mucosal drug delivery systems. Coating of liposomes by mucoadhesive polymers succeeded in enhancing immune responses. Our studies aim at preparation and characterization of trimethylchitosan-...

two deoxyglucose (dg) derivatives, (α,β)-2-deoxy-2-amino(ethylcarbamate)-d-glucose (ecb-dg) and (α,β)-2-deoxy-2-amino(1,2-dihydroxypropyl)-d-glucose (dhp-dg), were synthesized and radiolabeled successfully with [99mtc(h2o)3(co)3]+ complex. [99mtc]-ecb-dg and [99mtc]-dhp-dg complexes were prepared (96% and 93% radiochemical purities respectively) by using 46 mci of na99mtco4 in 1 ml saline. radi...

UNLABELLED 99mTc(N)-DBODC5 is the lead compound of a new series of monocationic 99mTc(N)-based potential myocardial imaging agents that exhibit original biodistribution properties. This study was addressed to elucidate the mechanisms of distribution, retention, and elimination of this promising 99mTc(N)-agent. METHODS The sex-related in vitro and in vivo stability and the subcellular distribu...

We read the article by Dr. Futrakul et al. with interest [1]. They searched for a parameter that was more sensitive than microalbuminuria for early detection of diabetic nephropathy and compared creatinine clearence, fractional excretion of magnesium and intrarenal hemodynamics by renal scintigraphic evaluation. For this purpose, they calculated peritubular capillary flow, efferent arteriolar r...

Discovery of osteitis may be delayed because of late appearance of X-ray signs in patients with diabetic foot. Scintigraphy with labelled leukocytes is able to detect flogosis but often misses bone involvement, due to inadequate resolution of Anger camera, the commonest detector used in nuclear medicine. Radioguided surgery and biopsy with high resolution scintigraphy (HRS) started to be studie...

Background: Diuretic renography using 99mTc-mercaptoacetyltriglycine (99mTc-MAG3) is a relatively non-invasive technique and has been increasingly used as reliable for the evaluation of kidney function in wide range disorders. Methods: In this retrospective study, we retrieved medical records patients referred to Radiology Department Radiology, King Abdulaziz Specialist Hospital, Taif, Saudi Ar...

Her technetium-99m diethylenetriaminepentaacetic acid (99mTc-DTPA) radioaerosol inhalation lung scintigraphy (May 21, 2008) revealed marked hypoventilation of the left lung and retention of the radiotracer in the right peri-hilar region, suggestive of a parenchymal process. The use of 99mTC human albumin macroaggregates (99mTC MAA) revealed no perfusion in the left lung and perfusion defects in...

Two deoxyglucose (DG) derivatives, (α,β)-2-deoxy-2-amino(ethylcarbamate)-D-glucose (ECB-DG) and (α,β)-2-deoxy-2-amino(1,2-dihydroxypropyl)-D-glucose (DHP-DG), were synthesized and radiolabeled successfully with [99mTc(H2O)3(CO)3]+ complex. [99mTc]-ECB-DG and [99mTc]-DHP-DG complexes were prepared (96% and 93% radiochemical purities respectively) by using 46 mCi of Na99mTcO4 in 1 mL saline. Radi...

Technetium-99m (99mTc) is one of the most desirable radionuclides for external imaging in diagnostic nuclear medicine, due to the emission of gamma ray of optimal energy (140 keV), a suitable half-life (6 h), and availability from 99Mo-99mTc generator systems. In addition, development of 99mTc radiopharmaceuticals for tumor imaging paves the way for therapeutic radiopharmaceuticals with high en...