We assessed the prognostic significance of preoperative serum carcinoembryonic antigen (CEA), carbohydrate antigen 19-9 (CA19-9) and carbohydrate antigen 242 (CA242) levels in surgically treated colorectal cancer patients. The relationship of preoperative serum CEA, CA19-9 and CA242 levels with disease characteristics was investigated in 310 patients. Correlation between tumor markers was inves...

BACKGROUND Serum dermokine (DK) is a novel biomarker for early colorectal cancer. To our knowledge this is the first study of DK expression in intraductal papillary mucinous neoplasm (IPMN) and pancreatic cancer. MATERIALS AND METHODS DK expression in human pancreatic cancer cell lines and tissues was assessed. We compared the sensitivities of common diagnostic markers, carbohydrate antigen 1...

Shigella strains are in reality clones of Escherichia coli and are believed to have emerged relatively recently (G. M. Pupo, R. Lan, and P. R. Reeves, Proc. Natl. Acad. Sci. USA 97:10567-10572, 2000). There are 33 O-antigen forms in these Shigella clones, of which 12 are identical to O antigens of other E. coli strains. We sequenced O-antigen gene clusters from Shigella boydii serotypes 4, 5, 6...

To define the role of the CD2-lymphocyte function-associated antigen 3 (LFA-3) interaction in T-cell activation, we have expressed a cDNA encoding the human CD2 molecule in a murine antigen-specific T-cell hybridoma. Expression of the CD2 molecule greatly enhances T-cell responsiveness to antigen; this enhancement is inhibited by anti-CD2 and anti-LFA-3 monoclonal antibodies (mAbs). CD2+ hybrid...

HYPOTHESIS Despite advances in preoperative radiologic imaging, a significant fraction of potentially resectable pancreatic cancers are found to be unresectable at laparotomy. We tested the hypothesis that preoperative serum levels of CA19-9 (cancer antigen) and carcinoembryonic antigen will identify patients with unresectable pancreatic cancer despite radiologic staging demonstrating resectabl...

conclusions non-invasive assessment of hepatic fibrosis could be done using the egy-score. egy-score could differentiate no or early fibrosis (stage f0-f2 metavir) from severe fibrosis or cirrhosis (stage f3 - f4 metavir) with 83.7% accuracy. results combined elevation of ca 19-9 and ca 125 with a summated value > 37 u/ml is predictive of severe hepatic fibrosis or cirrhosis (stage f3-f4 metavi...

Background: Numerous studies have suggested that differentially expressed miRNAs may be promising diagnostic markers for pancreatic cancer (PC), but the results are inconsistent. We aimed to summarize accuracy of circulating miRNAs, carbohydrate antigen 19-9 (CA19-9), and combination CA19-9. Material Methods: A literature search online databases including PubMed, EMBASE, Cochrane Library, China...

food borne viral infections are recognized increasingly as human illneses. hepatitis a virus (hav) is an important pathogen which has been responsible for water and many food – borne outbreeks especially milk . in this study for approaching to best diagnosis method of hav in milk by elisa technique, various dilutions of hav antigen (1 ml/l, 10-3 ml/l, 10-6 ml/l, 10-9 ml/l) were added to uht mil...

Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive malignancies with a 5-year survival rate less than 8%, which has remained unchanged over last 50 years. Early detection particularly difficult due to lack disease-specific symptoms and reliable biomarker. Multimodality treatment including chemotherapy, radiotherapy (used sparingly) surgery become standard care for patients PD...

Liu H, Hu B, Huang J, Wang Q, F, Pan F and Chen L (2022) Endoplasmic Reticulum Aminopeptidase 1 Is Involved in Anti-viral Immune Response of Hepatitis B Virus by Trimming Core Antigen to Generate 9-Mers Peptides. Front. Microbiol. 13:829241. doi: 10.3389/fmicb.2022.829241 Due a production error, Reviewer was erroneously named the published article. The name has been removed.The publisher apolog...