BACKGROUND Epothilones are cytotoxic macrolides that share a similar mechanism of action with the taxanes but demonstrate antitumor activity in taxane-resistant settings. Six epothilones are in early clinical trials for cancer treatment. DESIGN This review summarizes data from phase II clinical studies of the epothilones ixabepilone (BMS-247550), patupilone (EPO906), and KOS-862. Data were id...

The purpose of the study was to analyse and update consumers’ changing preferences in choice citrus fruit juices evaluate sensory physicochemical characteristics two kinds juices: juice squeezed from raw a commercial indicated by respondents as best matching their preferences. survey conducted form an online posted on app.ankieteo.pl. also sent via link through social networks. A total 862 peop...

This study aims to find out how control raw material inventory which is traditionally carried by the Tempeh Soybean Factory analyzing using Economic Order Quantity (EOQ) and Periodic (POQ) methods. In this study, we uses a descriptive-qualitative approach. The author observation, interviews, documentation in collecting data. resource persons consisted of factory owners, assistants, employees at...

Abstract An assessment of liquefaction potential for the Kathmandu Valley considering seasonal variability groundwater table has been conducted. To gain deeper understanding seven historical records located adjacent to borehole datapoints (published in SAFER/GEO-591) were used compare two methods estimation potential. Standard Penetration Test (SPT) blowcount data from 75 boreholes inform new m...

Nakazato G., Campos T.A., Stehling E.G., Brocchi M. & Silveira W.D. 2009. Virulence factors of avian pathogenic Escherichia coli (APEC). Pesquisa Veterinária Brasileira 29(7):479-486. Departamento de Microbiologia e Imunologia, Instituto de Biologia, Universidade Estadual de Campinas (Unicamp), Cidade Universitária Zeferino Vaz s/n, Cx. Postal 6109, Barão Geraldo, Campinas, SP 13081-862, Brazil...

Background—It is estimated that about half of cardiovascular disease risk is explained by conventional risk factors. The realization that atherosclerosis is an inflammatory disease has led to a search for new stroke and cardiovascular disease risk factors and treatments. As such, the vulnerable atherosclerotic plaque has become the main focus for new medical strategies for plaque stabilization ...

Exposure to parental depression and anxiety is known to heighten the risk of internalizing symptoms and disorders in children and adolescents. Ample research has focused on the influence of maternal depression and anxiety, but the contribution of psychopathology in fathers remains unclear. We studied the relationships of perceived maternal and paternal psychopathology with adolescents' depressi...