Mycophenolic acid (MPA) is a relatively new immunosuppressive drug, used since the nineties for the prevention of rejection in kidney transplantation. MPA has not only proved effective in preventing rejection, being even superior to azathioprine, but also seems to cause less adverse effects than other immunosuppressive drugs [1]. Because of these favourable experiences with MPA in renal transpl...

Focused ultrasound, in the presence of microbubbles, has been used non-invasively to induce reversible blood-brain barrier (BBB) opening in both rodents and non-human primates. This study was aimed at identifying the dependence of BBB opening properties on polydisperse microbubble (all clinically approved microbubbles are polydisperse) type and distribution by using a clinically approved ultras...

Patterns of connectivity and self-recruitment are recognized as key factors shaping the dynamics of marine populations. Connectivity is also essential for maintaining and restoring natural ecological processes with genetic diversity contributing to the adaptation and persistence of any species in the face of global disturbances. Estimates of connectivity are crucial to inform the design of both...

The aim of this study was to compare the shear bond strength (SBS) of brackets bonded to fluorosed and non-fluorosed teeth with self-etching primer (SEP) and phosphoric acid (PA). The study involved 40 mildly fluorosed [Thylstrup-Fejerskov (TFT) Index = 1-3] and 40 non-fluorosed human premolar teeth. The fluorosed and non-fluorosed teeth were randomly divided into two subgroups. In the first su...

STUDY OBJECTIVES To determine if coadministration of polysaccharide iron complex and slow-release ferrous sulfate alter the absorption of mycophenolic acid (MPA), and to examine the potential influence of dosing relative to mycophenolate mofetil (MMF) administration and the effect of immediate- versus sustained-release iron products on the steady-state pharmacokinetics of MPA. DESIGN Prospect...

STUDY DESIGN A prospective study in a hospital. PURPOSE To investigate whether each disability based on the three sub-categories of the Roland-Morris disability questionnaire (RDQ) during hospitalization is associated with itself at 1 year postoperatively in patients with degenerative lumbar spinal stenosis (LSS). OVERVIEW OF LITERATURE Although the total score of the RDQ represents whole p...

BACKGROUND Mycophenolic acid has been shown to be effective for the prevention and treatment of renal allograft rejection. Rejection episodes were found to be associated with an infiltration of lymphocytes and macrophages/monocytes into the diseased kidney. Expression of RANTES, HLA-DR and ICAM-1 may be important for the pathogenesis of this leukocyte infiltration. Therefore the aim of this stu...

In this technical report we define an operational net semantics for the stochastic process algebra MPA based on generalized stochastic Petri nets. As a consequence of the definition of such a semantics, we present an interesting modeling technique for concurrent systems which is based on MPA. 1. Dipartimento di Matematica, Università di Bologna, Piazza di Porta S. Donato 5, 40127 Bologna, Italy.

The effect, of varying the proportion of binder starch paste (SP) and the disintegrant sodium starch glycolate (SSG), on the compaction behavior of wet granulated acetaminophen (ACM) formulations using a fully instrumented rotary tablet press, was studied. Wet granulation formulations were prepared using ACM, SP as binder (equal to 2.5%, 5% or 10% starch concentration), SSG as disintegrant (0%,...

Process algebras are one of the main tools for modeling and analyzing concurrent systems. However, they can be used to describe only the functional aspect of system behavior. Recently, the relevance of integrating performance evaluation within the process of speciication, design and implementation of concurrent systems has been widely recognized. Hence, an eeort has been made in order to handle...