Metabolic change in cancer cells by preferential production of energy through glycolysis is a well-documented characteristic of cancer. However, whether inhibition of glycolysis will enhance the efficacy of radiation therapy is a matter of debate. In this study which uses lung cancer as the model, we demonstrate that the improvement of radiotherapy by 2-deoxy-D-glucose (2DG) is p53-dependent. B...

ownload ctive enhancement of tumor response to radiation therapy is a highly attractive objective, but it has not et clinically. Gain-of-function Ras (gf) signaling via hyperactivation of receptor tyrosine kinases, such epidermal growth factor receptor (EGFR), or via oncogenic mutation of Ras is shown to confer radionce and requires the engagement of the Raf/MEK/ERK pathway. However, upstream m...

Telomerase is a type of reverse transcriptase that is overexpressed in almost all human tumor cells, but not in normal tissues, which provides an opportunity for radiosensitization targeting telomerase. Zidovudine, abacavir and lamivudine are reverse transcriptase inhibitors that have been applied in clinical practice for several years. We sought to explore the radiosensitization effect of thes...

Gold nanoparticle (GNP) can be used as a radiation sensitizer in radiotherapy, and many Monte Carlo simulation studies have focused on this issue. A nanodosimetry biophysics Monte Carlo code NASIC was used in this work to study both the physical and biological radiosensitization effect of GNP in the cell environment under the irradiation of X-ray. GNP-cell models were built in the simulation wi...

This report introduces the overview and main mechanism of hyperthermia and summarizes the clinical application of hyperthermia in integrative natural therapies of cancer. According to the clinical experiences of the author, through statistical analysis, this report explains the orientation, application, and efficacy evaluation of hyperthermia in integrative natural therapies of cancer, as well ...

1. The pharmacology of the acute hyperthermia that follows 3,4-methylenedioxymethamphetamine (MDMA, 'ecstasy') administration to rats has been investigated. 2. MDMA (12.5 mg kg(-1) i.p.) produced acute hyperthermia (measured rectally). The tail skin temperature did not increase, suggesting that MDMA may impair heat dissipation. 3. Pretreatment with the 5-HT(1/2) antagonist methysergide (10 mg k...

We have previously reported that the use of the polymer bis(p-carboxyphenoxy)propane-sebacic acid (20:80) for intratumoral delivery of cis-platinum in a mouse tumor model (RIF-1) potentiated the effects of acute and fractionated radiation. This mode of drug delivery seems particularly applicable to the administration of radiosensitizing drugs because an optimum concentration of radiosensitizer ...

A novel therapy is demonstrated utilizing magnetic nanoparticles for the dual purpose of delivering microRNA and inducing magnetic hyperthermia. In particular, the combination of lethal-7a microRNA (let-7a), which targets a number of the survival pathways that typically limit the effectiveness of hyperthermia, with magnetic hyperthermia greatly enhances apoptosis in brain cancer cells.

Background Mild hyperthermia (41.5-44°C) has been shown to enhance the effect of radiotherapy and chemotherapy. However, currently available heating methods are often inefficient in inducing conformal hyperthermia for deep seated targets. Here, the software of Philips Sonalleve V2 MR-HIFU system was modified to enable performing a long duration large volume hyperthermia sonication in in-vivo po...

The review by Rampersaud and colleagues provides an excellent summary of the scientific rationale for using hyperthermia to treat cancer and of the current status of combinations of hyperthermia and chemotherapy or radiotherapy. In view of the demonstrated efficacy of the combination of intravescial hyperthermia and mitomycin C (MMC) therapy in preventing the progression and recurrence of non–m...