نتایج جستجو برای: 68ga psma

تعداد نتایج: 2775  

Journal: :International Journal of Radiation Oncology*Biology*Physics 2020

Journal: :Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2015
Martina Weineisen Margret Schottelius Jakub Simecek Richard P Baum Akin Yildiz Seval Beykan Harshad R Kulkarni Michael Lassmann Ingo Klette Matthias Eiber Markus Schwaiger Hans-Jürgen Wester

UNLABELLED On the basis of the high and consistent expression of prostate-specific membrane antigen (PSMA) in metastatic prostate cancer (PC), the goal of this study was the development, preclinical evaluation, and first proof-of-concept investigation of a PSMA inhibitor for imaging and therapy (PSMA I&T) for (68)Ga-based PET and (177)Lu-based endoradiotherapeutic treatment in patients with met...

Journal: :Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2017
Klaus Kopka Martina Benešová Cyril Bařinka Uwe Haberkorn John Babich

In recent years, several radioligands targeting prostate-specific membrane antigen (PSMA) have been clinically introduced as a new class of theranostic radiopharmaceuticals for the treatment of prostate cancer (PC). In the second decade of the 21st century, a new era in nuclear medicine was initiated by the clinical introduction of small-molecule PSMA inhibitor radioligands, 40 y after the clin...

Journal: :Molecular cancer therapeutics 2011
Xinning Wang Dangshe Ma William C Olson Warren D W Heston

Prostate-specific membrane antigen (PSMA) is a membrane protein that is overexpressed manifold in prostate cancer and provides an attractive target for therapy. PSMA ADC is an antibody-drug conjugate (ADC) that consists of a fully human anti-PSMA monoclonal antibody conjugated to monomethylauristatin E through a valine-citrulline linker. In this study, the antitumor activity of PSMA ADC was eva...

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