نتایج جستجو برای: 642 and 496
تعداد نتایج: 16827814 فیلتر نتایج به سال:
BACKGROUND Na(+)/H(+) exchange inhibition with HOE642 (cariporide) improves postischemic recovery of cardiac function, but the mechanisms of action remain speculative. Because Na(+)/H(+) exchange is activated on reperfusion, it was hypothesized that its inhibition delays realkalinization and decreases intracellular Na(+) and, via Na(+)/Ca(2+) exchange, Ca(2+) overload. Attenuated Ca(2+) overloa...
Isolated cardiomyocytes from adult rats were incubated in anoxic bicarbonate-buffered media at extracellular pH (pH(o)) 6.4 until a cytosolic Ca(2+) overload and intracellular pH (pH(i)) of 6.4 were reached. On reoxygenation, the pH of the medium was changed to 7.4 to activate the Na(+)/H(+)exchanger (NHE) and the Na(+)-HCO(-)(3) symporter (NBS). The reoxygenation was performed in the absence o...
OBJECTIVE Removal of protons from the heart during ischemia and/or reperfusion by the cardiac Na(+)/H(+) exchanger (NHE1) leads to Na(+) entry; this causes Ca(2+) influx and is thought to contribute to ischemic and/or reperfusion damage. The extent to which Na(+) enters during ischemia as opposed to reperfusion is disputed and has important implications for the therapeutic use of NHE1 inhibitor...
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