In cancers with wild-type (WT) p53 status, the function of p53 is inhibited through direct interaction with Mdm2 oncoprotein, a negative feedback loop to limit the function of p53. In response to cellular stress, p53 escapes the p53:Mdm2 negative feedback to accumulate rapidly to induce cell cycle arrest and apoptosis. We demonstrate herein that an microRNA miR-605 is a new component in the p53...

Previous studies revealed pharmacological differences between human and guinea pig histamine H(2) receptors (H(2)Rs) with respect to the interaction with guanidine-type agonists. Because H(2)R species variants are structurally very similar, comparative studies are suited to relate different properties of H(2)R species isoforms to few molecular determinants. Therefore, we systematically compared...

Deprotonation of 1-arylimidazoles (aryl = mesityl (Mes), 2,6-diisopropylphenyl (Dipp)), with n-butyl lithium afforded the corresponding derivatives (1-aryl-1H-imidazol-2-yl)lithium (1a, Ar = Mes; 1b, Ar = Dipp) in good yield. Reaction of 1a with 0.5 equiv. of [Ir(cod)(μ-Cl)]2 yielded two geometrical isomers of a doubly C2,N3-bridged dinuclear complex [Ir(cod){μ-C3H2N2(Mes)-κC2,κN3}]2 (3), 3H-H,...

Ramos de Almeida, J. M., and Rosado, L. (1972). Archives of Disease in Childhood, 47, 609. Rh blood group of grandmother and incidence of erythroblastosis. Maternal red cells may cross the placental barrier and enter the fetal circulation, and this transfer may cause primary sensitization in Rh-negative girls born to Rh-positive mothers. 60 families were studied. Each family consisted of the gr...

In order to facilitate oxidative addition chemistry of fac-coordinated rhodium(I) and iridium(I) compounds, carbene–bis(oxazolinyl)phenylborate proligands have been synthesized and reacted with organometallic precursors. Two proligands, PhB(OxMe2)2(ImtBuH) (H[1]; OxMe2 = 4,4-dimethyl-2-oxazoline; ImtBuH = 1-tert-butylimidazole) and PhB(OxMe2)2(ImMesH) (H[2]; ImMesH = 1-mesitylimidazole), are de...

The complex [ { Rh(p-Pz)(CNBut)2)2] (1) acts as a supernucleophile due to the strong basicity induced by the isocyanide ligands. It reacts rapidly with halocarbons (RX) such as PhCH2Cl or Me1 to give the cationic dirhodium(II1) complexes of formula [ { Rh(p-Pz)(R)(CNBut)2)2(p-X)]X. These reactions are stereoselective since the single stereoisomer formed presents both organic groups ( P h C H 2 ...

Photocatalytic hydrogen production was studied with a formic acid solution titanium dioxide (TiO2) the aid of simultaneous Rh deposition. The optimum conditions were as follows: loading, 0.1 wt%; concentration, 1.0%; solution, pH 2.2; temperature, 50 °C. Under conditions, photocatalytic TiO2 by deposition 5.0 mmol g−1, 12.2 g−1 and 16.0 after 1 h, 3 h 5 irradiation time for black light, respect...

We are constructing high-resolution, chromosomal 'test' maps for the entire pig genome using a 12,000-rad WG-RH panel (IMNpRH2(12,000-rad))to provide a scaffold for the rapid assembly of the porcine genome sequence. Here we present an initial, comparative map of human chromosome (HSA) 11 with pig chromosomes (SSC) 2p and 9p. Two sets of RH mapping vectors were used to construct the RH framework...