Although various therapies are available to treat cancers, including surgery, chemotherapy, and radiotherapy, cancer has been the leading cause of death in Japan for the last 30 years, and new therapeutic modalities are urgently needed. As a new modality, there has recently been great interest in oncolytic virotherapy, with measles virus being a candidate virus expected to show strong antitumor...

Background: In order to deliver the precise dose to the target in radiotherapy, absorbed dose to water at the reference point should be assessed. When the calibration procedure is performed for a reference dosimeter in the 60Co beam of a Secondary Standard Dosimetry Laboratory (SSDL), the total uncertainty in absorbed dose to water (Dw) is estimated to be approximately 1.5%. This study attempts...

Background: Accurate small radiation field dosimetry is essential in modern radiotherapy techniques such as stereotactic radiosurgery (SRS) and intensity modulated radiotherapy (IMRT). Precise measurement of dosimetric parameters such as beam profile, percentage depth doses and output factor of these beams are complicated due to the electron disequilibrium and the steep dose gradients. In the p...

Introduction: In radiotherapy, the bolus is often used while treating the tumor under the uneven surfaces of the patients for correcting the anatomical irregularities and increasing skin dose. Wet cotton and wet gauze are still used in developing countries, since the use of wet cotton and wet gauze has certain disadvantages, there is a need for transparent bolus which ...

Introduction: The aim of this study is to investigate the effect of partially used high photon energies on dosimetric parameters and integral doses of nasopharynx IMRT plans.   Materials and Methods: Two 7 coplanar IMRT plan were created for eleven patients (6 MV only IMRT plan in both phase1 and phase2 and 6 MV phase1-mixed energies (6 MV and 15 MV) phase2...

OBJECTIVE Radiochromic EBT3 film is a later generation of radiochromic films. The aim of this study is to compare EBT and EBT3 radiochromic films in radiotherapy fields of breast cancer. METHODS A RANDO phantom was irradiated by a 6 MV Siemens Primus linac with medial and lateral fields of radiotherapy of breast cancer. Dosimetry was performed in various points in the fields using EBT and EBT...

The treatment of ovarian cancer has traditionally been intractable, and required novel approaches to improve therapeutic efficiency. This paper reports that thio-glucose bound gold nanoparticles (Glu-GNPs) can be used as a sensitizer to enhance ovarian cancer radiotherapy. The human ovarian cancer cells, SK-OV-3, were treated by gold nanoparticles (GNPs) alone, irradiation alone, or GNPs in add...

Background Chemoradiotherapy plays an important role in management of locally advanced head and neck cancers. This retrospective analysis was done to evaluate and compare acute toxicity profiles and early clinical outcomes in patients treated with conventional and arc techniques. Methods Fifty-five patients of head and neck cancers were evaluated. Thirty patients received conventional radioth...

DOSI, a novel dosimeter based on position sensitive detectors for particle physics experiments, was used for relative clinical dosimetry measurements in small radiotherapy fields. The device is capable of dynamic measurements in real time and provides sub-millimetre spatial resolution. The basic beam data for a stereotactic radiotherapy collimator system (BrainLAB) using 6 MV photons were measu...

Introduction Bolus is a soft and resilient material which is used for increasing skin dose or to even out the irregular patient contour. The main property of various materials used presently as bolus is the water-equivalent electron density. Ethyl methacrylate is used as a soft-liner in dentistry and its physical and chemical properties are proved to be nontoxic for human body. The goal of this...