To identify mutations that cause hereditary hemorrhagic telangiectasia (HHT, or Rendu-Osler-Weber syndrome), clinical evaluations and genetic studies were performed on 32 families. Linkage studies in four of eight families indicated an endoglin (ENG) gene mutation. ENG sequences of affected members of the four linked families and probands from the 24 small families were screened for mutations, ...

The solution to the canonical problem of a radiating infinitesimal electric dipole antenna that is centred in a multilayered, concentric metamaterial-based spherical shell system is presented. It is demonstrated that when this system is electrically small, a specifically designed homogenous and isotropic epsilon-negative (ENG) layer can function as a distributed matching element to the antenna ...

OBJECTIVE To determine if angiogenesis is altered in adult Endoglin heterozygous (Eng(+/-)) mice, the animal model for the vascular disorder hereditary hemorrhagic telangiectasia type 1 (HHT1). METHODS Primary cultures of endothelial cells were generated from Eng(+/-) and Eng(+/+) mice and analyzed for proliferation, migration, and ability to form capillary-like tubes. Endothelial cells deriv...

The University of Texas at Austin, Departm Beijing National Laboratory of Molecular Bioorganic Chemistry and Molecular Eng University, Beijing, 100871, China Key Laboratory of Pesticide & Chemical B Chemistry, Central China Normal Universit † Electronic supplementary informa 10.1039/c5sc00584a ‡ Current address: Pzer Inc., Eastern P States. § AD and REW contributed equally. Cite this: Chem. Sc...

Department of Chemistry and the Inter Northwestern University, 2145 Sheridan Ro E-mail: [email protected] Department of Chemical & Biological Eng Sheridan Road, Evanston, IL, 60208, USA † Electronic supplementary information ( the synthesis of hierarchically porous orga (gas adsorption–desorption isotherms, por and density data). Detailed procedures calculation of diffusion constants. See DO...

Endoglin (ENG), an ancillary receptor for several members of the transforming growth factor (TGF)-beta superfamily, has a well-studied role in endothelial function. Here, we report that endoglin also plays an important role early in development at the level of the hemangioblast, an embryonic progenitor of the hematopoietic and endothelial lineages. Eng(-/-), Eng(+/-) and Eng(+/+) mouse embryoni...

BACKGROUND Renal ischaemia-reperfusion (I-R) can cause acute tubular necrosis and chronic renal deterioration. Endoglin, an accessory receptor for Transforming Growth Factor-beta1 (TGF-beta1), is expressed on activated endothelium during macrophage maturation and implicated in the control of fibrosis, angiogenesis and inflammation. METHODS Endoglin expression was monitored over 14 days after ...

BACKGROUND AND PURPOSE Endoglin deficiency causes hereditary hemorrhagic telangiectasia-1 and impairs myocardial repair. Pulmonary arteriovenous malformations in patients with hereditary hemorrhagic telangiectasia-1 are associated with a high incidence of paradoxical embolism in the cerebral circulation and ischemic brain injury. We hypothesized that endoglin deficiency impairs stroke recovery....

Objective – This study demonstrates one method of developing and applying rubrics to student writing in order to gather evidence of how students utilize information literacy skills in the context of an authentic assessment activity. The process of creating a rubric, training scorers to use the rubric, collecting annotated bibliographies, applying the rubric to student work, and the results of t...

ADVERTISEMENT RETURN TO ISSUEEditorialNEXTSustainable Additive Manufacturing of PlasticsHaritz SardonHaritz SardonMore by Haritz Sardonhttps://orcid.org/0000-0002-6268-0916, Timothy LongTimothy LongMore Long, and Hortense Le FerrandHortense FerrandMore Ferrandhttps://orcid.org/0000-0003-3017-9403Cite this: ACS Sustainable Chem. Eng. 2022, 10, 6, 1983–1985Publication Date (Web):February 14, 2022...