Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a rare potentially life-threatening genetic heart disease. Non-selective beta-blockers (BBs, namely nadolol and propranolol) are highly effective in reducing CPVT-triggered arrhythmic events. However, some patients suffer from unacceptable BB side effects might require BB-free treatment strategies that include flecainide, left card...

The accelerating trend toward Faster, Better, Cheaper (FEE) missions places increasing emphas is on the trade-offs between requirements and risk to reduce cost and development times, while still improving quality and reliability. The Risk/Requirenlents Trade-off Guidelines discussed in this paper are part of an integrated approach to address the main issues by focusing on the sum of prevention,...

occupational exposure to elemental mercury vapor usually occurs through inhalation during its utilizations. this leads to a variety of adverse health effects. in some islamic cities, this type of poisoning may occur during gilding of shrines using elemental mercury with gold. herein, we report on three male patients aged 20–53 years, who were diagnosed with occupational metallic mercury poisoni...

BACKGROUND Evidence, mainly from cross-sectional studies, suggests that physical activity is a potentially important modifiable factor associated with physical performance and strength in older age. It is unclear whether the benefits of physical activity accumulate across life or whether there are sensitive periods when physical activity is more influential. PURPOSE To examine the association...

INTRODUCTION Iatrogenic visceral injuries (IVI) secondary to the insertion of an intercostal chest drain (ICD) are well documented, but are usually confined to case reports and small series. MATERIALS AND METHODS We reviewed our experience with 53 consecutive patients over a insertion seven year period who sustained an IVI secondary to an ICD and describe the spectrum of injuries and clinical...

A Holocene lake sediment record spanning the past 7300 years from Wishart Lake in the Turkey Lakes Watershed in the Hemi-Boreal of central Ontario, Canada, was used to evaluate the potential drivers of long-term change in diatom assemblages at this site. An analysis of diatom assemblages found that benthic and epiphytic taxa dominated the mid-Holocene (7300-4000 cal yr BP), indicating shallow, ...